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• W2087683419 abstract "Interictal high-frequency oscillations (HFOs, 80-500Hz) can predict the seizure onset zone (SOZ), but visual detection of HFOs is time consuming. Time-frequency analysis can reveal large high-frequency (HF) power changes (80-500Hz) associated with inter-ictal spikes. The present study determines how well the rate of HFOs and spike-related HF power changes were co-localized with SOZ.We analyzed 583 channels (68 in the SOZ) sampled from 14 patients who underwent intracranial EEG recording. We determined if the rate of visually-marked HFOs and spike-related HF power changes differed between SOZ and non-SOZ.Significantly higher rates of HFOs were found in SOZ. The degree of spike-related HF power augmentation failed to differ between SOZ and non-SOZ, whereas that of post-spike HF power attenuation was significantly more severe in SOZ compared to in non-SOZ. Regions showing HFOs and large spike-related HF-changes showed a partial overlap in distribution in 7/14 patients.Strong HF augmentation during spikes and high HFO rates occurred over different brain locations. The rate of HFOs showed the best performance in identifying SOZ. Post-spike HF power attenuation may represent increased inhibition in these channels and should be investigated further.Strong HF power changes during spikes and HFOs per se seem to reflect distinct phenomena." @default.
• W2087683419 created "2016-06-24" @default.
• W2087683419 creator A5006528993 @default.
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• W2087683419 date "2016-01-01" @default.
• W2087683419 modified "2023-10-16" @default.
• W2087683419 title "The identification of distinct high-frequency oscillations during spikes delineates the seizure onset zone better than high-frequency spectral power changes" @default.
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• W2087683419 doi "https://doi.org/10.1016/j.clinph.2015.04.053" @default.
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• W2087683419 hasPublicationYear "2016" @default.
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