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- W2087689081 abstract "The objective of this study was to investigate the effects of amlodipine, a dihydropyridine calcium channel blocker, on renal microvasculature in hypertensive rats. Hydronephrosis was induced by permanent ligation of the left ureter in 8-week-old spontaneously hypertensive rats. After the hydronephrotic left kidney was split longitudinally and spread out as a thin sheet, the renal microvasculature was observed directly under a light microscope. Administration of amlodipine 200 μg/kg caused a gradual fall in systolic blood pressure (39 mm Hg). The afferent arterioles were dilated and maintained the same level of dilation after 60 minutes (19% at 5 minutes and 21% at 60 minutes at the diameter). The efferent arterioles were similarly dilated (14% at 5 minutes and 18% at 60 minutes). The glomerular blood flow was significantly increased (28% at 5 minutes and 46% at 60 minutes). We concluded that amlodipine dilated both the afferent and efferent arterioles and increased the glomerular blood flow." @default.
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- W2087689081 date "1997-06-01" @default.
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- W2087689081 title "Effects of amlodipine, a calcium channel blocker, on rat renal arterioles" @default.
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- W2087689081 doi "https://doi.org/10.1016/s0011-393x(97)80096-3" @default.
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