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• W2087691821 abstract "You have accessJournal of UrologyImaging/Radiology: Uroradiology II1 Apr 20102143 REAL TIME DELINEATION PROSTATIC ARCHITECTURE USING ROBO-MICROSCOPY PROJECT TWO PHOTON LASER EXCITATION IMAGING IN VISUALIZATION OF HUMAN PROSTATIC TISSUE Mike Herman, Ashutosh Tewari, Sushmita Mukherjee, Rajiv Yadav, Fred Maxfield, Sonal Grover, Kumaran Mudaliar, Youssef El Douaihy, Abhishek Srivastava, Mark Rubin, Warren R. Zipfel, David Peters, Robert Leung, Maria Shevchuk, DaWei Ye, Gerald Tan, Josh Sterling, and Watt W. Webb Mike HermanMike Herman More articles by this author , Ashutosh TewariAshutosh Tewari More articles by this author , Sushmita MukherjeeSushmita Mukherjee More articles by this author , Rajiv YadavRajiv Yadav More articles by this author , Fred MaxfieldFred Maxfield More articles by this author , Sonal GroverSonal Grover More articles by this author , Kumaran MudaliarKumaran Mudaliar More articles by this author , Youssef El DouaihyYoussef El Douaihy More articles by this author , Abhishek SrivastavaAbhishek Srivastava More articles by this author , Mark RubinMark Rubin More articles by this author , Warren R. ZipfelWarren R. Zipfel More articles by this author , David PetersDavid Peters More articles by this author , Robert LeungRobert Leung More articles by this author , Maria ShevchukMaria Shevchuk More articles by this author , DaWei YeDaWei Ye More articles by this author , Gerald TanGerald Tan More articles by this author , Josh SterlingJosh Sterling More articles by this author , and Watt W. WebbWatt W. Webb More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2244AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES This is the study to validate our hypothesis that two photon laser imaging (Robo-Microscopy Project) can be used for imaging the prostate gland architecture and to improve intraoperative differentiation of cancer from benign tissue, thus allowing a more complete cancer removal. METHODS We used tissue sections obtained from the excised prostate. The imaging was carried out using intrinsic fluorescence and scattering properties of the tissues without any exogenous dye or contrast agent. A custom-built imaging tool (Robo-Microscope Project), with a femtosecond pulsed titanium/sapphire laser at 780-nm wavelength was used to excite the tissue; laser power under the objective was modulated via a Pockels cell. Signals were collected at 390 (+/-35 nm), and broadband autofluorescence was collected at 380 to 530 nm. In certain cases, longer wavelength autofluorescence was collected at 530-650 nm. The images obtained from tissue fluorescence were then merged and color coded during post processing for better appreciation of details. The corresponding tissues were subjected to hematoxylin and eosin staining for histological confirmation of the structures. RESULTS On higher magnifications, the acini were clearly distinguishable from the surrounding stroma, and the basement membrane appeared intact. The morphology and arrangement of the cells is roughly the same as in traditional pathology. Figure 1 shows benign cells forming well defined glands where as Figure 2 shows the histopathologic appearance of prostate cancer (B), which lacks individual glands and often fail to form lumens. Robo-Microscopy Project images from the same section also show poorly defined glandular structures (panel A). CONCLUSIONS Our study shows that optical microscopy can assist in differentiating and diagnosing prostate cancer from noncancerous tissues. Further studies will better define its role in actual clinical setting. New York, NY© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e833 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mike Herman More articles by this author Ashutosh Tewari More articles by this author Sushmita Mukherjee More articles by this author Rajiv Yadav More articles by this author Fred Maxfield More articles by this author Sonal Grover More articles by this author Kumaran Mudaliar More articles by this author Youssef El Douaihy More articles by this author Abhishek Srivastava More articles by this author Mark Rubin More articles by this author Warren R. Zipfel More articles by this author David Peters More articles by this author Robert Leung More articles by this author Maria Shevchuk More articles by this author DaWei Ye More articles by this author Gerald Tan More articles by this author Josh Sterling More articles by this author Watt W. Webb More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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