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- W2087693296 abstract "The neuropeptide eclosion hormone (EH) is a key regulator of insect ecdysis. We tested the role of the two EH-producing neurons in Drosophila by using an EH cell-specific enhancer to activate cell death genes reaper and head involution defective to ablate the EH cells. In the EH cell knockout flies, larval and adult ecdyses were disrupted, yet a third of the knockouts emerged as adults, demonstrating that EH has a significant but nonessential role in ecdysis. The EH cell knockouts had discrete behavioral deficits, including slow, uncoordinated eclosion and an insensitivity to ecdysis-triggering hormone. The knockouts lacked the lights-on eclosion response despite having a normal circadian eclosion rhythm. This study represents a novel approach to the dissection of neuropeptide regulation of a complex behavioral program." @default.
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- W2087693296 date "1997-10-01" @default.
- W2087693296 modified "2023-10-18" @default.
- W2087693296 title "Disruption of a Behavioral Sequence by Targeted Death of Peptidergic Neurons in Drosophila" @default.
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- W2087693296 doi "https://doi.org/10.1016/s0896-6273(00)80963-0" @default.
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