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- W2087700437 abstract "Hormones, or at least conditions now known to be under hormonal control (growth, reproduction, behaviour), have an ancient heritage In human culture. The assembling of endocrine organs into a system alongside the gut, cardiovascular or nervous systems is relatively recent. All vertebrates have, with occasional exception, a similar set of endocrine glands with secretions that are chemically identical (steroids, thyroid hormones, catecholamines) or which belong to the ‘families’ of peptide, polypeptide or protein hormones. To be efficacious, these materials must interact with their specific receptors which may be within the genome itself or a protein within or on the cell membrane. The production of many hormones may not be unique to particular glands, and may. Indeed, be produced by all cells. From their site of synthesis, hormones may be transported in the blood stream (endocrine) to their receptors, act locally on neighbouring cells (paracrine), act on the cell producing them (automne) or merely act within the cell of origin (intracrine). Hormones are produced Initially as precursors which are acted upon in a cascade fashion by enzymes. The nature of the substrate and mutations in the genes coding for the substrate or the enzyme influence the degrees to which hormones are conserved in an evolutionary sense. Many hormones do not act directly, but act by Inducing the production of other hormones which act In a paracrine fashion." @default.
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- W2087700437 date "1994-06-01" @default.
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- W2087700437 title "Historical aspects and contemporary concepts and developments in endocrinology" @default.
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- W2087700437 doi "https://doi.org/10.1080/00219266.1994.9655374" @default.
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