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- W2087702953 endingPage "13" @default.
- W2087702953 startingPage "3" @default.
- W2087702953 abstract "Summary Background Alcoholic hepatitis is a severe, cholestatic liver disease occurring in patients with alcohol abuse. Mortality is substantial; however, therapies may improve clinical outcomes. Aim To provide an updated review of the epidemiology, diagnosis, staging and treatment of alcoholic hepatitis. Methods A MEDLINE literature search was performed to identify pertinent articles. Relevant clinical abstracts were also reviewed. Results Severe alcoholic hepatitis occurs in a small fraction of patients who abuse alcohol. The 28‐day mortality ranges from 30% to 50% in most series. Diagnosis is generally based on clinical features, with a limited role for liver biopsy. Beneficial treatment options include alcohol abstinence and nutritional therapy. Despite variable results in clinical trials, corticosteroids and pentoxifylline appear to provide moderate survival benefit. Anti‐tumour necrosis factor agents and antioxidants have not proven beneficial, and should be limited to clinical trials. Liver transplant is not a frequent option given the active or recent alcohol use. Conclusions Severe alcoholic hepatitis is a clinically‐diagnosed condition associated with significant mortality. Alcohol abstinence and nutritional therapy have been associated with improved clinical parameters and should be considered in all patients. Corticosteroid therapy and pentoxifylline therapy appear to show moderate survival benefit and should be considered as first‐line therapeutic agents." @default.
- W2087702953 created "2016-06-24" @default.
- W2087702953 creator A5029369824 @default.
- W2087702953 creator A5075687052 @default.
- W2087702953 date "2009-06-15" @default.
- W2087702953 modified "2023-10-15" @default.
- W2087702953 title "Review article: the diagnosis and management of alcoholic hepatitis" @default.
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