FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087706707> ?p ?o ?g. }

• W2087706707 abstract "Lysophosphatidic acid (LPA) mediates cholestatic pruritus. Recently the enzyme PNPLA3, expressed in liver and skin, was demonstrated to metabolise LPA. Here we assess the association of the PNPLA3 variant p.Ile148Met, known to be associated with (non-)alcoholic fatty liver disease (NAFLD) in genome-wide association studies, with cholestatic itch in 187 patients with primary biliary cirrhosis (PBC) and 250 PBC-free controls as well as 201 women with intrahepatic cholestasis of pregnancy (ICP) and 198 female controls without a history of ICP. Our hypothesis was that the intensity of cholestatic itch differs in carriers of distinct PNPLA3 p.Ile148Met genotypes. Patients with PBC carrying the allele p.148Met that confers an increased NAFLD risk reported less itching than carriers of the p.148Ile allele (ANOVA P = 0.048). The PNPLA3 p.148Ile allele increased the odds of requiring plasmapheresis for refractory pruritus (OR = 3.94, 95% CI = 0.91-17.00, P = 0.048). In line with these findings, the PNPLA3 p.148Met allele was underrepresented in the ICP cohort (OR = 0.66, 95% CI = 0.47-0.92, P = 0.013). Notwithstanding the need for further replication of these findings, we conclude that the PNPLA3 allele p.148Met might confer protection against cholestatic pruritus, possibly due to increased LPA-acyltransferase activity in liver and/or skin." @default.
• W2087706707 created "2016-06-24" @default.
• W2087706707 creator A5013003026 @default.
• W2087706707 creator A5019879976 @default.
• W2087706707 creator A5027288774 @default.
• W2087706707 creator A5037066892 @default.
• W2087706707 creator A5068247828 @default.
• W2087706707 creator A5078832883 @default.
• W2087706707 creator A5080862113 @default.
• W2087706707 creator A5086203679 @default.
• W2087706707 date "2014-10-09" @default.
• W2087706707 modified "2023-10-17" @default.
• W2087706707 title "Variant adiponutrin confers genetic protection against cholestatic itch" @default.
• W2087706707 cites W185418824 @default.
• W2087706707 cites W1966197398 @default.
• W2087706707 cites W1996299724 @default.
• W2087706707 cites W2002621738 @default.
• W2087706707 cites W2017511982 @default.
• W2087706707 cites W2019108167 @default.
• W2087706707 cites W2037842760 @default.
• W2087706707 cites W2038946905 @default.
• W2087706707 cites W2068053039 @default.
• W2087706707 cites W2086838245 @default.
• W2087706707 cites W2093976705 @default.
• W2087706707 cites W2096694584 @default.
• W2087706707 cites W2108087274 @default.
• W2087706707 cites W2134836501 @default.
• W2087706707 cites W2138842039 @default.
• W2087706707 cites W2149047916 @default.
• W2087706707 cites W2153909270 @default.
• W2087706707 cites W2157724595 @default.
• W2087706707 doi "https://doi.org/10.1038/srep06374" @default.
• W2087706707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4190538" @default.
• W2087706707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25297933" @default.
• W2087706707 hasPublicationYear "2014" @default.
• W2087706707 type Work @default.
• W2087706707 sameAs 2087706707 @default.
• W2087706707 citedByCount "6" @default.
• W2087706707 countsByYear W20877067072015 @default.
• W2087706707 countsByYear W20877067072016 @default.
• W2087706707 countsByYear W20877067072021 @default.
• W2087706707 crossrefType "journal-article" @default.
• W2087706707 hasAuthorship W2087706707A5013003026 @default.
• W2087706707 hasAuthorship W2087706707A5019879976 @default.
• W2087706707 hasAuthorship W2087706707A5027288774 @default.
• W2087706707 hasAuthorship W2087706707A5037066892 @default.
• W2087706707 hasAuthorship W2087706707A5068247828 @default.
• W2087706707 hasAuthorship W2087706707A5078832883 @default.
• W2087706707 hasAuthorship W2087706707A5080862113 @default.
• W2087706707 hasAuthorship W2087706707A5086203679 @default.
• W2087706707 hasBestOaLocation W20877067071 @default.
• W2087706707 hasConcept C104317684 @default.
• W2087706707 hasConcept C106208931 @default.
• W2087706707 hasConcept C126322002 @default.
• W2087706707 hasConcept C134018914 @default.
• W2087706707 hasConcept C135763542 @default.
• W2087706707 hasConcept C153209595 @default.
• W2087706707 hasConcept C156957248 @default.
• W2087706707 hasConcept C172680121 @default.
• W2087706707 hasConcept C180754005 @default.
• W2087706707 hasConcept C2778593092 @default.
• W2087706707 hasConcept C2778772119 @default.
• W2087706707 hasConcept C2779134260 @default.
• W2087706707 hasConcept C2779224579 @default.
• W2087706707 hasConcept C2779234561 @default.
• W2087706707 hasConcept C54355233 @default.
• W2087706707 hasConcept C71924100 @default.
• W2087706707 hasConcept C86803240 @default.
• W2087706707 hasConcept C90924648 @default.
• W2087706707 hasConceptScore W2087706707C104317684 @default.
• W2087706707 hasConceptScore W2087706707C106208931 @default.
• W2087706707 hasConceptScore W2087706707C126322002 @default.
• W2087706707 hasConceptScore W2087706707C134018914 @default.
• W2087706707 hasConceptScore W2087706707C135763542 @default.
• W2087706707 hasConceptScore W2087706707C153209595 @default.
• W2087706707 hasConceptScore W2087706707C156957248 @default.
• W2087706707 hasConceptScore W2087706707C172680121 @default.
• W2087706707 hasConceptScore W2087706707C180754005 @default.
• W2087706707 hasConceptScore W2087706707C2778593092 @default.
• W2087706707 hasConceptScore W2087706707C2778772119 @default.
• W2087706707 hasConceptScore W2087706707C2779134260 @default.
• W2087706707 hasConceptScore W2087706707C2779224579 @default.
• W2087706707 hasConceptScore W2087706707C2779234561 @default.
• W2087706707 hasConceptScore W2087706707C54355233 @default.
• W2087706707 hasConceptScore W2087706707C71924100 @default.
• W2087706707 hasConceptScore W2087706707C86803240 @default.
• W2087706707 hasConceptScore W2087706707C90924648 @default.
• W2087706707 hasIssue "1" @default.
• W2087706707 hasLocation W20877067071 @default.
• W2087706707 hasLocation W20877067072 @default.
• W2087706707 hasLocation W20877067073 @default.
• W2087706707 hasLocation W20877067074 @default.
• W2087706707 hasOpenAccess W2087706707 @default.
• W2087706707 hasPrimaryLocation W20877067071 @default.
• W2087706707 hasRelatedWork W1555993317 @default.
• W2087706707 hasRelatedWork W1991443076 @default.
• W2087706707 hasRelatedWork W2076965288 @default.
• W2087706707 hasRelatedWork W2098258710 @default.
• W2087706707 hasRelatedWork W2161349865 @default.
• W2087706707 hasRelatedWork W2281456597 @default.

• next