FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087716009> ?p ?o ?g. }

• W2087716009 endingPage "46" @default.
• W2087716009 startingPage "39" @default.
• W2087716009 abstract "Different aspects on the structure-activity relationships, the pharmacokinetic and the pharmacodynamic properties of the benzodiazepines (BDZs) are briefly outlined, followed by a more thorough description of the current hypothesis on the mode of action of these drugs, focusing on the supramolecular GABA-BDZ-chloride-ionophore receptor complex. The existence of different synthetic ligands for the receptor exerting opposite effects is discussed together with the recent finding in mammals of an endogenous ligand with anxiogenic-like effects. The possibility of the anxiolytic effects of the BDZs being related to actions on monoaminergic systems is also briefly mentioned. A new group of BDZs, the triazolo-BDZs, is described. One of these compounds, alprazolam (APZ), exhibits a different clinical profile as compared to traditional BDZs. Apart from being effective in the treatment of generalized anxiety, it has been proven effective also in the treatment of panic disorder. Some studies also indicate anti-depressant effects of the compound. The reason for these apparent unique effects of APZ is not clear. A brief description of a commonly applied animal model (the Vogel conflict model) for the study of anxiety-related mechanisms is given and original animal data from experiments aiming at elucidating the mechanism behind the anti-panic effect of APZ are presented. The results indicate that tolerance to different pharmacodynamic effects of APZ and the traditional BDZ diazepam (DIZ) develop to different extents. Thus, tolerance development to the ataxic/sedative effects of APZ was pronounced, whereas no significant tolerance developed to the anxiolytic-like effects. For DIZ, however, tolerance development was pronounced to both the anxiolytic-like and the ataxic/sedative effects.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2087716009 created "2016-06-24" @default.
• W2087716009 creator A5058391664 @default.
• W2087716009 date "1987-09-01" @default.
• W2087716009 modified "2023-09-24" @default.
• W2087716009 title "Pharmacology of the benzodiazepines; with special emphasis on alprazolam" @default.
• W2087716009 cites W1966466951 @default.
• W2087716009 cites W1973381993 @default.
• W2087716009 cites W1976440389 @default.
• W2087716009 cites W1978342290 @default.
• W2087716009 cites W1979021279 @default.
• W2087716009 cites W1980755879 @default.
• W2087716009 cites W1982904143 @default.
• W2087716009 cites W1983404085 @default.
• W2087716009 cites W1984930321 @default.
• W2087716009 cites W1988705766 @default.
• W2087716009 cites W1990666576 @default.
• W2087716009 cites W1991861023 @default.
• W2087716009 cites W1994148459 @default.
• W2087716009 cites W1994429680 @default.
• W2087716009 cites W2007911341 @default.
• W2087716009 cites W2016942629 @default.
• W2087716009 cites W2019366801 @default.
• W2087716009 cites W2019776775 @default.
• W2087716009 cites W2021004252 @default.
• W2087716009 cites W2022692847 @default.
• W2087716009 cites W2024545561 @default.
• W2087716009 cites W2026240508 @default.
• W2087716009 cites W2026920124 @default.
• W2087716009 cites W2031244179 @default.
• W2087716009 cites W2039884272 @default.
• W2087716009 cites W2043205243 @default.
• W2087716009 cites W2043598410 @default.
• W2087716009 cites W2069644518 @default.
• W2087716009 cites W2080359769 @default.
• W2087716009 cites W2081594365 @default.
• W2087716009 cites W2083934238 @default.
• W2087716009 cites W2085958346 @default.
• W2087716009 cites W2087773637 @default.
• W2087716009 cites W2092901298 @default.
• W2087716009 cites W2094320944 @default.
• W2087716009 cites W2123441365 @default.
• W2087716009 cites W2135810618 @default.
• W2087716009 cites W2404274155 @default.
• W2087716009 cites W4232428024 @default.
• W2087716009 cites W4243622623 @default.
• W2087716009 doi "https://doi.org/10.1111/j.1600-0447.1987.tb07747.x" @default.
• W2087716009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2823537" @default.
• W2087716009 hasPublicationYear "1987" @default.
• W2087716009 type Work @default.
• W2087716009 sameAs 2087716009 @default.
• W2087716009 citedByCount "28" @default.
• W2087716009 countsByYear W20877160092014 @default.
• W2087716009 countsByYear W20877160092016 @default.
• W2087716009 countsByYear W20877160092019 @default.
• W2087716009 countsByYear W20877160092020 @default.
• W2087716009 countsByYear W20877160092021 @default.
• W2087716009 crossrefType "journal-article" @default.
• W2087716009 hasAuthorship W2087716009A5058391664 @default.
• W2087716009 hasConcept C111113717 @default.
• W2087716009 hasConcept C112705442 @default.
• W2087716009 hasConcept C118552586 @default.
• W2087716009 hasConcept C126322002 @default.
• W2087716009 hasConcept C15744967 @default.
• W2087716009 hasConcept C170493617 @default.
• W2087716009 hasConcept C185592680 @default.
• W2087716009 hasConcept C205044023 @default.
• W2087716009 hasConcept C2776175493 @default.
• W2087716009 hasConcept C2777196872 @default.
• W2087716009 hasConcept C2777602617 @default.
• W2087716009 hasConcept C2777765862 @default.
• W2087716009 hasConcept C2778173252 @default.
• W2087716009 hasConcept C558461103 @default.
• W2087716009 hasConcept C71924100 @default.
• W2087716009 hasConcept C98274493 @default.
• W2087716009 hasConceptScore W2087716009C111113717 @default.
• W2087716009 hasConceptScore W2087716009C112705442 @default.
• W2087716009 hasConceptScore W2087716009C118552586 @default.
• W2087716009 hasConceptScore W2087716009C126322002 @default.
• W2087716009 hasConceptScore W2087716009C15744967 @default.
• W2087716009 hasConceptScore W2087716009C170493617 @default.
• W2087716009 hasConceptScore W2087716009C185592680 @default.
• W2087716009 hasConceptScore W2087716009C205044023 @default.
• W2087716009 hasConceptScore W2087716009C2776175493 @default.
• W2087716009 hasConceptScore W2087716009C2777196872 @default.
• W2087716009 hasConceptScore W2087716009C2777602617 @default.
• W2087716009 hasConceptScore W2087716009C2777765862 @default.
• W2087716009 hasConceptScore W2087716009C2778173252 @default.
• W2087716009 hasConceptScore W2087716009C558461103 @default.
• W2087716009 hasConceptScore W2087716009C71924100 @default.
• W2087716009 hasConceptScore W2087716009C98274493 @default.
• W2087716009 hasIssue "S335" @default.
• W2087716009 hasLocation W20877160091 @default.
• W2087716009 hasLocation W20877160092 @default.
• W2087716009 hasOpenAccess W2087716009 @default.
• W2087716009 hasPrimaryLocation W20877160091 @default.
• W2087716009 hasRelatedWork W1554825335 @default.
• W2087716009 hasRelatedWork W1799463129 @default.

• next