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- W2087723764 abstract "From the results of in vitro investigations Crane developed the hypothesis of co-transport or symport for intestinal sugar absorption [ 1, 21, which assumes that the carrier forms a ternary complex with the nonelectrolytes to be transported and with the sodium ion (for details see: [l-3]). According to this hypothesis the uphill transport of a nonelectrolyte is effected by the simultaneous downhill transport of sodium. Application of this carrier model to intestinal glucose absorption requires that at least two conditions should be fulfilled: i) For uphill transport of glucose out of the intestinal lumen an opposite downhill concentration gradient for sodium is required. ii) There should be a stoichiometric coupling between glucose uptake and sodium uptake by the intestinal epithelium. To test these minimal requirements investigations in vivo would be required. However, until now no direct evidence for the sodium gradient hypothesis has been obtained by in vivo investigations [4,5]. Therefore, additional in vitro investigations performed with an intestinal preparation under optimal conditions were desirable." @default.
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- W2087723764 date "1973-04-01" @default.
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- W2087723764 title "Some comments on the coupling between intestinal absorption of glucose and of sodium" @default.
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- W2087723764 doi "https://doi.org/10.1016/0014-5793(73)80076-6" @default.
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