Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087729971> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2087729971 endingPage "298" @default.
- W2087729971 startingPage "293" @default.
- W2087729971 abstract "Candoxatrilat is a potent and selective inhibitor of neutral endopeptidase (EC 3.4.24.11), the enzyme responsible for the degradation of atrial natriuretic factor (ANF). In these studies, the renal effects of candoxatrilat were in euvolemic and hypervolemic anaesthetised rats. In euvolemic rats, candoxatrilat (675 μg/kg per h) had no effect on urine output, sodium and potassium excretion or urinary cyclic GMP excretion. However, in hypervolemic rats, the natriuretic responses to volume expansion were markedly potentiated by the candoxatrilat infusion, with a concomitant increase in urinary cyclic GMP. Acute volume expansion was characterised by natriuresis, diuresis and increased levels of plasma ANF and cyclic GMP (1.5-fold and 2-fold increases respectively, when compared to euvolemic rats). The results presented suggest that plasma ANF levels and volume status modulate responses to neutral endopeptidase inhibition. The development of the neutral endopeptidase inhibitor, candoxatrilat, provides the opportunity to exploit endogenous ANF effectively in disease state with elevated ANF." @default.
- W2087729971 created "2016-06-24" @default.
- W2087729971 creator A5015637084 @default.
- W2087729971 date "1988-04-01" @default.
- W2087729971 modified "2023-09-23" @default.
- W2087729971 title "Role of Atriopeptin in Blood Pressure Regulation" @default.
- W2087729971 cites W1520611194 @default.
- W2087729971 cites W1984176897 @default.
- W2087729971 cites W1984646238 @default.
- W2087729971 cites W1989514987 @default.
- W2087729971 cites W1990683043 @default.
- W2087729971 cites W2000860526 @default.
- W2087729971 cites W2006386829 @default.
- W2087729971 cites W2015283139 @default.
- W2087729971 cites W2017522610 @default.
- W2087729971 cites W2021642938 @default.
- W2087729971 cites W2029212741 @default.
- W2087729971 cites W2035880299 @default.
- W2087729971 cites W2041479733 @default.
- W2087729971 cites W2051744140 @default.
- W2087729971 cites W2052097767 @default.
- W2087729971 cites W2052792277 @default.
- W2087729971 cites W2065265905 @default.
- W2087729971 cites W2072379197 @default.
- W2087729971 cites W2141247331 @default.
- W2087729971 doi "https://doi.org/10.1097/00000441-198804000-00013" @default.
- W2087729971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2966580" @default.
- W2087729971 hasPublicationYear "1988" @default.
- W2087729971 type Work @default.
- W2087729971 sameAs 2087729971 @default.
- W2087729971 citedByCount "6" @default.
- W2087729971 crossrefType "journal-article" @default.
- W2087729971 hasAuthorship W2087729971A5015637084 @default.
- W2087729971 hasConcept C10146269 @default.
- W2087729971 hasConcept C104826730 @default.
- W2087729971 hasConcept C126322002 @default.
- W2087729971 hasConcept C134018914 @default.
- W2087729971 hasConcept C16613235 @default.
- W2087729971 hasConcept C174459258 @default.
- W2087729971 hasConcept C181199279 @default.
- W2087729971 hasConcept C185592680 @default.
- W2087729971 hasConcept C2778069365 @default.
- W2087729971 hasConcept C2779547328 @default.
- W2087729971 hasConcept C2780091579 @default.
- W2087729971 hasConcept C55493867 @default.
- W2087729971 hasConcept C71924100 @default.
- W2087729971 hasConceptScore W2087729971C10146269 @default.
- W2087729971 hasConceptScore W2087729971C104826730 @default.
- W2087729971 hasConceptScore W2087729971C126322002 @default.
- W2087729971 hasConceptScore W2087729971C134018914 @default.
- W2087729971 hasConceptScore W2087729971C16613235 @default.
- W2087729971 hasConceptScore W2087729971C174459258 @default.
- W2087729971 hasConceptScore W2087729971C181199279 @default.
- W2087729971 hasConceptScore W2087729971C185592680 @default.
- W2087729971 hasConceptScore W2087729971C2778069365 @default.
- W2087729971 hasConceptScore W2087729971C2779547328 @default.
- W2087729971 hasConceptScore W2087729971C2780091579 @default.
- W2087729971 hasConceptScore W2087729971C55493867 @default.
- W2087729971 hasConceptScore W2087729971C71924100 @default.
- W2087729971 hasIssue "4" @default.
- W2087729971 hasLocation W20877299711 @default.
- W2087729971 hasLocation W20877299712 @default.
- W2087729971 hasOpenAccess W2087729971 @default.
- W2087729971 hasPrimaryLocation W20877299711 @default.
- W2087729971 hasRelatedWork W1980957264 @default.
- W2087729971 hasRelatedWork W1994945884 @default.
- W2087729971 hasRelatedWork W2002038679 @default.
- W2087729971 hasRelatedWork W2036863687 @default.
- W2087729971 hasRelatedWork W2048449846 @default.
- W2087729971 hasRelatedWork W2156834205 @default.
- W2087729971 hasRelatedWork W2212154849 @default.
- W2087729971 hasRelatedWork W2473470765 @default.
- W2087729971 hasRelatedWork W3087580008 @default.
- W2087729971 hasRelatedWork W2186282964 @default.
- W2087729971 hasVolume "295" @default.
- W2087729971 isParatext "false" @default.
- W2087729971 isRetracted "false" @default.
- W2087729971 magId "2087729971" @default.
- W2087729971 workType "article" @default.