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- W2087743966 abstract "3β-Chlorosteroids, such as cholesteryl β-chloride and sitosteryl β-chloride, are formed during the production of protein hydrolysates, which are useful flavour enhancers. These chlorinated steroids may also attract attention as environmental contaminants if they are released from liquid crystal display devices. The effects of orally administered 3β-chlorosteroids were tested in female NMRI mice. The animals were fed cholesteryl β-chloride or sitosteryl β-chloride at doses of 1 mg and 10 mg/animal/day, that is, 33 mg and 330 mg body weight/day, over a period of 3 months. Feed intake, body weight and organ weights of the animals, as well as concentration of 3β-chlorosteroids in faeces and various organs and tissues showed that cholesteryl β-chloride and sitosteryl β-chloride are not acutely toxic compounds. However, chronic toxicity cannot be excluded because small amounts of 3β-chlorosteroids, in particular cholesteryl β-chloride, were absorbed by the intestinal tract and accumulated in adipose tissue. Histopathological examination of sections of organs and tissues showed no indication of irreversible cell damage in the stomach, duodenum, liver, kidneys and spleen caused by the chlorinated steroids." @default.
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- W2087743966 date "1994-04-01" @default.
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- W2087743966 title "3β-Chlorosteroids: Artefacts and possible contaminants in food and feed—Toxicological effects in mice" @default.
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- W2087743966 doi "https://doi.org/10.1016/0278-6915(94)90068-x" @default.
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