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- W2087777234 abstract "Abstract The levels of estradiol 17β-dehydrogenase activity have been found to be more than 10 times higher in secretory human endometrium than in proliferative tissue. Since in vitro experiments indicated that the bulk of estradiol (E 2 ) entering endometrial cells is released back to the medium as estrone (E 1 ), the effect of changes in the E 2 17β-dehydrogenase activity on the intracellular concentrations of E 2 and E 1 could be predicted and verified experimentally. In the luteal phase of the menstrual cycle E 2 presented to endometrium contributes less to the intracellular E 2 pool and more to the E 1 pool than an equal amount of E 2 presented to endometrium in the proliferative phase. Estradiol and not E 1 showed tight binding to nuclear pellets after the incubation of slices of endometrium with labeled estrogens. The observed competitive effect of E 1 on the binding of E 2 could be accounted for by the intracellular conversion of E 1 to E 2 . The total amount of estradiol receptor levels was found to be drastically reduced during the luteal phase. Preliminary in vivo experiments indicated that progesterone is responsible for this reduction and for the increase of the 17β-dehydrogenase activity. These observations point to means of regulating E 2 receptor levels and E 2 intracellular concentrations in normal tissue and possibly in endometrial cancer." @default.
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- W2087777234 date "1974-08-01" @default.
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- W2087777234 title "Factors controlling intracellular levels of estrogens in human endometrium" @default.
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- W2087777234 doi "https://doi.org/10.1016/0090-8258(74)90011-0" @default.
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