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- W2087781806 abstract "Rats were injected with 5.0 mg/kg of p-chloroamphetamine (PCA) or saline from 1–28 days of age. Groups treated with PCA showed hypoactivity in the open field at 29, 50 and 75 days of age when compared to rats treated with saline and facilitated avoidance in Y-maze acquisition at 57–61 days of age. At 36 and 68 days of age, at the time of behavioral testing, brain serotonin (5HT) was reduced slightly or not at all. However, in separate groups, brain 5HT was reduced 23% and 35% in 14 and 26 day-old rats after only a single treatment with PCA, suggesting that 5HT was reduced during the treatment period. At 66–68 days of age, 5HT turnover was also unaltered. These results suggest that the behavioral effects were due to neonatal 5HT depletion during a critical period of development rather than a concurrent 5HT depletion at the time of behavioral testing. Moreover, these data are at variance with the concept that neonatal 5HT depletion impairs learning ability and is the underlying CNS defect in phenylketonuria." @default.
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- W2087781806 date "1974-11-01" @default.
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- W2087781806 title "p-Chloroamphetamine: Evidence against a serotonin mediated learning deficit in PKU" @default.
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- W2087781806 doi "https://doi.org/10.1016/0091-3057(74)90111-7" @default.
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