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- W2087783233 abstract "The angle of cell division is critical in at least two contexts. It can determine cell fate, as it does in developing neural tissue. It can also dictate tissue architecture, as it does in many epithelia. One way to ensure the correct angle of cell division is through controlled orientation of the spindle at metaphase. What happens when that control is lost? Ongoing work suggests that the consequence of metaphase spindle misorientation may be significant, but multiple mechanisms exist to protect the cell and the tissue. We speculate that one such mechanism involves a recently identified anaphase activity for two of the key players at metaphase: NuMA (Mud, LIN-5) and dynein." @default.
- W2087783233 created "2016-06-24" @default.
- W2087783233 creator A5027640574 @default.
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- W2087783233 date "2014-10-01" @default.
- W2087783233 modified "2023-10-09" @default.
- W2087783233 title "Spindle orientation: What if it goes wrong?" @default.
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- W2087783233 doi "https://doi.org/10.1016/j.semcdb.2014.06.014" @default.
- W2087783233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4169663" @default.
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