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- W2087788194 abstract "N 1965, intracellular iron inclusions were found in biopsy material from the ventrolateral nucleus of the thalamus and from other organs of patients with Parkinson's disease, 4 obtained by means of the AsenjoImbern6n stereotaxic technique? This finding led to research in which 100 mg of iron in the form of iron dextran were injected intravenously every week into 40 rabbits and 12 monkeys (Cebus albijrons) up to a total dose of 3 to 4 gm. When the rabbits had received a cumulative dose of 800 mg of iron, and the monkeys, 500 mg, they developed a peculiar tremor that was evident clinically and electromyographically. These neurophysiological findings have already been published in detail? Method The animals were killed successively after different cumulative doses had been reached, always 7 days after the last injection. Both injected and control animals were treated as follows. Under general anesthesia, the deep jugular veins were dissected. The left cardiac ventricle was punctured, and samples were obtained for blood iron and latent iron binding capacity determinations. Through the same puncture, the left cardiac ventricle was injected with 2 liters of isotonic sodium chloride solution. The proximal end of the jugular vein and the suprahepatic and cava veins above the diaphragm were ligated. Simultaneously, the distal ends of the jugular vein and of the suprahepatic vein were cut below the diaphragm. The abdominal aorta was ligated below the origin of the hepatic artery. Perfusion from the aorta through the carotid and hepatic arteries eliminated the circulating blood from the brain and liver; this is essential for correct measurement of tissue iron. The liver and brain were excised and" @default.
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- W2087788194 date "1970-06-01" @default.
- W2087788194 modified "2023-10-14" @default.
- W2087788194 title "Iron Concentration in Basal Ganglia and Cerebral Cortex Obtained by Overloading Rabbits and Monkeys with Iron Dextran" @default.
- W2087788194 cites W1580077463 @default.
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- W2087788194 doi "https://doi.org/10.3171/jns.1970.32.6.0677" @default.
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