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- W2087788662 abstract "Adriamycin (ADM) in a low weekly dose (10mg/M2) was used as a single agent for maintenance of remission (RMS) in 24 previously treated children with acute lymphoblastic leukemia (ALL). The dose was escalated by 2mg/M2 weekly until WBC count remained between 3,000-3,500/mm3. The therapy was discontinued when cummulative dose of ADM reached 500mg/M2, or changes compatible with ADM toxicity were demonstrated on echocardiogram. Results of therapy are shown in table: In 2 patients ADM was discontinued when cummulative dose of 500 mg/M2 was reached and they have remained in continuous RMS for 54+ and 152+ weeks respectively. The toxicity was minimal: myelosuppression 8/24; changes on echocardiogram 2/24. Although no strictly comparable historical groups are available, 8 weeks has been an average median duration of RMS in previously reported studies of unmaintained early RMS or later RMS, maintained by single agent. Our results demonstrate that weekly ADM can be effective in maintaining RMS in children with ALL." @default.
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- W2087788662 date "1978-04-01" @default.
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- W2087788662 title "613 ADRIAMYCIN AS A MAINTENANCE AGENT IN ACUTE LYMPHOBLASTIC LEUKEMIA" @default.
- W2087788662 doi "https://doi.org/10.1203/00006450-197804001-00618" @default.
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