FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087789006> ?p ?o ?g. }

• W2087789006 endingPage "F903" @default.
• W2087789006 startingPage "F895" @default.
• W2087789006 abstract "Significant reduction of renal mass initiates a series of hemodynamic and nonhemodynamic events which lead to proteinuria, glomerulosclerosis, tubulointerstitial injury, and end-stage renal failure. Lipid mediators derived from fatty acids participate in regulation of renal hemodynamic and nonhemodynamic processes that influence progression of renal disease. Composition of cellular fatty acids and hence related signaling responses are influenced by their dietary contents. Consumption of omega-3 fatty acids (O-3FA) has proven effective in mitigating atherosclerosis. We tested the hypothesis that O-3FA supplementation may retard progression and attenuate upregulation of pathways involved in oxidative stress, inflammation, and fibrosis in rats with renal mass reduction. Sprague-Dawley rats were subjected to 5/6 nephrectomy [chronic renal failure (CRF)] and randomly assigned to the untreated and O-3FA-treated (0.3 g·kg −1 ·day −1 by gastric gavage for 12 wk) groups. Sham-operated rats served as controls. The untreated CRF rats exhibited proteinuria, hypertension, azotemia, upregulations of renal tissue NAD(P)H oxidase, MCP-1, COX-2, PAI-1, TGF-β, Smad2, α-smooth muscle actin, fibronectin, and hepatocyte growth factor, activation of ERK1/2 and NF-κB, downregulation of Smad7, intense mononuclear leukocyte infiltration, tubulointerstitial fibrosis, and glomerulosclerosis. O-3FA supplementation significantly lowered COX-2, NAD(P)H oxidase (NOX-4, gp91 phox , p47 phox , p22 phox ), PAI-1, TGF-β, connective tissue growth factor, α-smooth muscle actin, fibronectin, Smad2, and MCP-1, raised Smad7, and attenuated ERK1/2 and NF-κB activation, tubulointerstitial fibrosis, and inflammation. Thus, long-term O-3FA supplementation can reduce or reverse upregulation of prooxidant, proinflammatory, and profibrotic pathways and attenuate tubulointerstitial fibrosis in the remnant kidney." @default.
• W2087789006 created "2016-06-24" @default.
• W2087789006 creator A5035495226 @default.
• W2087789006 creator A5051147472 @default.
• W2087789006 creator A5056238061 @default.
• W2087789006 creator A5075032078 @default.
• W2087789006 date "2009-10-01" @default.
• W2087789006 modified "2023-10-10" @default.
• W2087789006 title "Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney" @default.
• W2087789006 cites W1535924864 @default.
• W2087789006 cites W1774264327 @default.
• W2087789006 cites W1919436047 @default.
• W2087789006 cites W1964861133 @default.
• W2087789006 cites W1969816132 @default.
• W2087789006 cites W1985085970 @default.
• W2087789006 cites W1985836457 @default.
• W2087789006 cites W1996976658 @default.
• W2087789006 cites W1997431505 @default.
• W2087789006 cites W2016442066 @default.
• W2087789006 cites W2018160443 @default.
• W2087789006 cites W2023367990 @default.
• W2087789006 cites W2035093916 @default.
• W2087789006 cites W2045336146 @default.
• W2087789006 cites W2046401692 @default.
• W2087789006 cites W2052997652 @default.
• W2087789006 cites W2060773151 @default.
• W2087789006 cites W2061751751 @default.
• W2087789006 cites W2087394026 @default.
• W2087789006 cites W2092240515 @default.
• W2087789006 cites W2096976658 @default.
• W2087789006 cites W2111123038 @default.
• W2087789006 cites W2114345165 @default.
• W2087789006 cites W2125342732 @default.
• W2087789006 cites W2126151205 @default.
• W2087789006 cites W2128411304 @default.
• W2087789006 cites W2138236943 @default.
• W2087789006 cites W2145563725 @default.
• W2087789006 cites W2147068335 @default.
• W2087789006 cites W2147758809 @default.
• W2087789006 cites W2148244353 @default.
• W2087789006 cites W2148303421 @default.
• W2087789006 cites W2150541210 @default.
• W2087789006 cites W2157106870 @default.
• W2087789006 cites W2172164503 @default.
• W2087789006 cites W2183215439 @default.
• W2087789006 cites W2317298663 @default.
• W2087789006 cites W2335187016 @default.
• W2087789006 cites W4250450758 @default.
• W2087789006 cites W4297846773 @default.
• W2087789006 doi "https://doi.org/10.1152/ajprenal.00217.2009" @default.
• W2087789006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19656915" @default.
• W2087789006 hasPublicationYear "2009" @default.
• W2087789006 type Work @default.
• W2087789006 sameAs 2087789006 @default.
• W2087789006 citedByCount "124" @default.
• W2087789006 countsByYear W20877890062012 @default.
• W2087789006 countsByYear W20877890062013 @default.
• W2087789006 countsByYear W20877890062014 @default.
• W2087789006 countsByYear W20877890062015 @default.
• W2087789006 countsByYear W20877890062016 @default.
• W2087789006 countsByYear W20877890062017 @default.
• W2087789006 countsByYear W20877890062018 @default.
• W2087789006 countsByYear W20877890062019 @default.
• W2087789006 countsByYear W20877890062020 @default.
• W2087789006 countsByYear W20877890062021 @default.
• W2087789006 countsByYear W20877890062022 @default.
• W2087789006 countsByYear W20877890062023 @default.
• W2087789006 crossrefType "journal-article" @default.
• W2087789006 hasAuthorship W2087789006A5035495226 @default.
• W2087789006 hasAuthorship W2087789006A5051147472 @default.
• W2087789006 hasAuthorship W2087789006A5056238061 @default.
• W2087789006 hasAuthorship W2087789006A5075032078 @default.
• W2087789006 hasConcept C126322002 @default.
• W2087789006 hasConcept C134018914 @default.
• W2087789006 hasConcept C2776151105 @default.
• W2087789006 hasConcept C2776914184 @default.
• W2087789006 hasConcept C2777390665 @default.
• W2087789006 hasConcept C2778653478 @default.
• W2087789006 hasConcept C2779561371 @default.
• W2087789006 hasConcept C2779719074 @default.
• W2087789006 hasConcept C2780091579 @default.
• W2087789006 hasConcept C2780559512 @default.
• W2087789006 hasConcept C71924100 @default.
• W2087789006 hasConceptScore W2087789006C126322002 @default.
• W2087789006 hasConceptScore W2087789006C134018914 @default.
• W2087789006 hasConceptScore W2087789006C2776151105 @default.
• W2087789006 hasConceptScore W2087789006C2776914184 @default.
• W2087789006 hasConceptScore W2087789006C2777390665 @default.
• W2087789006 hasConceptScore W2087789006C2778653478 @default.
• W2087789006 hasConceptScore W2087789006C2779561371 @default.
• W2087789006 hasConceptScore W2087789006C2779719074 @default.
• W2087789006 hasConceptScore W2087789006C2780091579 @default.
• W2087789006 hasConceptScore W2087789006C2780559512 @default.
• W2087789006 hasConceptScore W2087789006C71924100 @default.
• W2087789006 hasIssue "4" @default.
• W2087789006 hasLocation W20877890061 @default.
• W2087789006 hasLocation W20877890062 @default.
• W2087789006 hasOpenAccess W2087789006 @default.

• next