FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087799446> ?p ?o ?g. }

• W2087799446 endingPage "572" @default.
• W2087799446 startingPage "563" @default.
• W2087799446 abstract "An angiotensin II-binding activity has been identified in the 100 000 × g supernatant fraction of adrenal gland, kidney, liver, heart and brain of adult rat. The binding is specific for angiotensin II; it is of high affinity and completely dependent upon the presence of an organomercurial, p-chloromercuriphenylsulfonic acid. Reducing agents, on the other hand, cause a dissociation of bound ligand. Covalent cross-linking of [125I]-angiotensin II to the soluble fraction from rat heart followed by SDS-polyacrylamide gel electrophoresis and autoradiography indicated that the macromolecule that binds angiotensin II is most probably a protein with an apparent mass of 78 000 dalton. A comparison of the binding of angiotensin II to the 100 000 × g supernatant fraction from both neonatal (1–3-day-old) and adult (3-month-old) rat hearts revealed that angiotensin II binds with similar affinity and specificity, but the number of binding sites is 3-fold higher in the neonatal heart (D and Bmax were 10.4 ± 3.1 nm and 1.6 ± 0.4 pmol/mg protein for adult and 8.8 ± 2.9 nm and 4.9 ± 0.7 pmol/mg protein for neonatal heart, respectively). The membrane fraction prepared from neonatal rat heart similarly bound angiotensin II in a saturable manner and with high affinity (D 4.3 ± 0.5 nm and Bmax 146.4 ± 4.9 fmol/mg protein), but a similar membrane fraction prepared from adult rat heart failed to show any angiotensin II binding. These observations indicated that, in rat heart, there is a decrease of angiotensin II-binding sites, both soluble and membrane bound, with age. Hence, rat heart, at various stages of development, and myocytes prepared from it should provide a suitable system with which to study the developmental regulation of the angiotensin II-binding protein." @default.
• W2087799446 created "2016-06-24" @default.
• W2087799446 creator A5025695582 @default.
• W2087799446 creator A5080244166 @default.
• W2087799446 date "1991-05-01" @default.
• W2087799446 modified "2023-09-27" @default.
• W2087799446 title "Angiotensin II-binding protein in adult and neonatal rat heart" @default.
• W2087799446 cites W1548207656 @default.
• W2087799446 cites W1575840121 @default.
• W2087799446 cites W1586912476 @default.
• W2087799446 cites W1595152081 @default.
• W2087799446 cites W1828569676 @default.
• W2087799446 cites W1933715094 @default.
• W2087799446 cites W1964545151 @default.
• W2087799446 cites W1965338581 @default.
• W2087799446 cites W1968256336 @default.
• W2087799446 cites W1972920641 @default.
• W2087799446 cites W1977441081 @default.
• W2087799446 cites W1980959388 @default.
• W2087799446 cites W1982470628 @default.
• W2087799446 cites W1988828899 @default.
• W2087799446 cites W1990469583 @default.
• W2087799446 cites W1997394311 @default.
• W2087799446 cites W1999422984 @default.
• W2087799446 cites W2003701057 @default.
• W2087799446 cites W2006258234 @default.
• W2087799446 cites W2007550314 @default.
• W2087799446 cites W2011142985 @default.
• W2087799446 cites W2014575233 @default.
• W2087799446 cites W2028784188 @default.
• W2087799446 cites W2029130094 @default.
• W2087799446 cites W2041333363 @default.
• W2087799446 cites W2042446681 @default.
• W2087799446 cites W2061205761 @default.
• W2087799446 cites W2072246490 @default.
• W2087799446 cites W2072730012 @default.
• W2087799446 cites W2072889338 @default.
• W2087799446 cites W2082702456 @default.
• W2087799446 cites W2084714640 @default.
• W2087799446 cites W2094208472 @default.
• W2087799446 cites W2107828529 @default.
• W2087799446 cites W2118581224 @default.
• W2087799446 cites W2128635872 @default.
• W2087799446 cites W2134215740 @default.
• W2087799446 cites W2162616464 @default.
• W2087799446 cites W2197787966 @default.
• W2087799446 cites W2413572360 @default.
• W2087799446 cites W2417374334 @default.
• W2087799446 cites W2418013042 @default.
• W2087799446 doi "https://doi.org/10.1016/0022-2828(91)90048-q" @default.
• W2087799446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1886136" @default.
• W2087799446 hasPublicationYear "1991" @default.
• W2087799446 type Work @default.
• W2087799446 sameAs 2087799446 @default.
• W2087799446 citedByCount "23" @default.
• W2087799446 countsByYear W20877994462022 @default.
• W2087799446 crossrefType "journal-article" @default.
• W2087799446 hasAuthorship W2087799446A5025695582 @default.
• W2087799446 hasAuthorship W2087799446A5080244166 @default.
• W2087799446 hasConcept C104317684 @default.
• W2087799446 hasConcept C104849204 @default.
• W2087799446 hasConcept C126322002 @default.
• W2087799446 hasConcept C134018914 @default.
• W2087799446 hasConcept C185592680 @default.
• W2087799446 hasConcept C198710026 @default.
• W2087799446 hasConcept C2780091579 @default.
• W2087799446 hasConcept C2908929049 @default.
• W2087799446 hasConcept C553089730 @default.
• W2087799446 hasConcept C55493867 @default.
• W2087799446 hasConcept C71924100 @default.
• W2087799446 hasConcept C84393581 @default.
• W2087799446 hasConcept C86803240 @default.
• W2087799446 hasConceptScore W2087799446C104317684 @default.
• W2087799446 hasConceptScore W2087799446C104849204 @default.
• W2087799446 hasConceptScore W2087799446C126322002 @default.
• W2087799446 hasConceptScore W2087799446C134018914 @default.
• W2087799446 hasConceptScore W2087799446C185592680 @default.
• W2087799446 hasConceptScore W2087799446C198710026 @default.
• W2087799446 hasConceptScore W2087799446C2780091579 @default.
• W2087799446 hasConceptScore W2087799446C2908929049 @default.
• W2087799446 hasConceptScore W2087799446C553089730 @default.
• W2087799446 hasConceptScore W2087799446C55493867 @default.
• W2087799446 hasConceptScore W2087799446C71924100 @default.
• W2087799446 hasConceptScore W2087799446C84393581 @default.
• W2087799446 hasConceptScore W2087799446C86803240 @default.
• W2087799446 hasIssue "5" @default.
• W2087799446 hasLocation W20877994461 @default.
• W2087799446 hasLocation W20877994462 @default.
• W2087799446 hasOpenAccess W2087799446 @default.
• W2087799446 hasPrimaryLocation W20877994461 @default.
• W2087799446 hasRelatedWork W1966128948 @default.
• W2087799446 hasRelatedWork W1987220778 @default.
• W2087799446 hasRelatedWork W2054593959 @default.
• W2087799446 hasRelatedWork W2077998387 @default.
• W2087799446 hasRelatedWork W2116067399 @default.
• W2087799446 hasRelatedWork W2126797993 @default.
• W2087799446 hasRelatedWork W2132612653 @default.
• W2087799446 hasRelatedWork W2149410839 @default.

• next