FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087799854> ?p ?o ?g. }

• W2087799854 endingPage "226" @default.
• W2087799854 startingPage "216" @default.
• W2087799854 abstract "Arsenic is known to produce inhibition as well as induction of immune cells proliferative responses depending on the doses as one of its mechanisms of immunotoxicity. Here we evaluate the effect of arsenic exposure on the activation of splenic mononuclear cells (SMC) in male CD57BL6N mice. Intra-gastric exposure to arsenic (as sodium arsenite) for 30 days (1, 0.1, or 0.01 mg/kg/day), reduced the proportion of CD4+ cells and the CD4+/CD8+ ratio in the spleen, increasing the proportion of CD11b+ cells. Arsenic exposure did not modify the proportion of B cells. SMC showed an increased level of phosphorylation of lck and fyn kinases (first kinases associated to TCR complex when activated). Although normal levels of apoptosis were observed on freshly isolated SMC, an increase in apoptotic cells related with the increase in phosphorylation of lck and fyn was observed when SMC were activated with Concanavalin-A (Con-A). Arsenic exposure reduced the proliferative response of SMC to Con-A, and also reduced secretion of IL-2, IL-6, IL-12 and IFNγ. No effect was observed on IL-4, and IL-10 secretion. The same effects were observed when SMC of exposed animals were activated with anti-CD3/CD28 antibodies for 24 h, but these effects were transitory since a recovery, up to control levels or even higher, were observed after 72 h of stimulation. This study demonstrates that repeated and prolonged exposure to arsenic alters cell populations and produces functional changes depending on the specific activation pathway, and could be related with the phosphorylation status of lck and fyn kinases." @default.
• W2087799854 created "2016-06-24" @default.
• W2087799854 creator A5057805790 @default.
• W2087799854 creator A5071756138 @default.
• W2087799854 date "2008-07-01" @default.
• W2087799854 modified "2023-09-23" @default.
• W2087799854 title "Arsenic interferes with the signaling transduction pathway of T cell receptor activation by increasing basal and induced phosphorylation of Lck and Fyn in spleen cells" @default.
• W2087799854 cites W1516802222 @default.
• W2087799854 cites W1552681886 @default.
• W2087799854 cites W1574848475 @default.
• W2087799854 cites W1679962258 @default.
• W2087799854 cites W1750024901 @default.
• W2087799854 cites W1964171854 @default.
• W2087799854 cites W1971384289 @default.
• W2087799854 cites W1971863753 @default.
• W2087799854 cites W1977455794 @default.
• W2087799854 cites W1984294697 @default.
• W2087799854 cites W1987512823 @default.
• W2087799854 cites W1987873876 @default.
• W2087799854 cites W1997724365 @default.
• W2087799854 cites W2013135659 @default.
• W2087799854 cites W2015817969 @default.
• W2087799854 cites W2017055313 @default.
• W2087799854 cites W2027766745 @default.
• W2087799854 cites W2034934067 @default.
• W2087799854 cites W2035029439 @default.
• W2087799854 cites W2036689701 @default.
• W2087799854 cites W2038999037 @default.
• W2087799854 cites W2043661250 @default.
• W2087799854 cites W2058793386 @default.
• W2087799854 cites W2059064361 @default.
• W2087799854 cites W2073307618 @default.
• W2087799854 cites W2076718022 @default.
• W2087799854 cites W2098954372 @default.
• W2087799854 cites W2108117968 @default.
• W2087799854 cites W2112469589 @default.
• W2087799854 cites W2113703610 @default.
• W2087799854 cites W2124301716 @default.
• W2087799854 cites W2125447747 @default.
• W2087799854 cites W2130231062 @default.
• W2087799854 cites W2130398420 @default.
• W2087799854 cites W2137921390 @default.
• W2087799854 cites W2142570075 @default.
• W2087799854 cites W2150769903 @default.
• W2087799854 cites W2157117401 @default.
• W2087799854 cites W2158175056 @default.
• W2087799854 cites W2170427580 @default.
• W2087799854 cites W2172221058 @default.
• W2087799854 cites W2961146810 @default.
• W2087799854 cites W4239149709 @default.
• W2087799854 cites W4376043923 @default.
• W2087799854 doi "https://doi.org/10.1016/j.taap.2008.02.029" @default.
• W2087799854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18407307" @default.
• W2087799854 hasPublicationYear "2008" @default.
• W2087799854 type Work @default.
• W2087799854 sameAs 2087799854 @default.
• W2087799854 citedByCount "59" @default.
• W2087799854 countsByYear W20877998542012 @default.
• W2087799854 countsByYear W20877998542013 @default.
• W2087799854 countsByYear W20877998542014 @default.
• W2087799854 countsByYear W20877998542015 @default.
• W2087799854 countsByYear W20877998542016 @default.
• W2087799854 countsByYear W20877998542017 @default.
• W2087799854 countsByYear W20877998542018 @default.
• W2087799854 countsByYear W20877998542019 @default.
• W2087799854 countsByYear W20877998542020 @default.
• W2087799854 countsByYear W20877998542021 @default.
• W2087799854 countsByYear W20877998542022 @default.
• W2087799854 countsByYear W20877998542023 @default.
• W2087799854 crossrefType "journal-article" @default.
• W2087799854 hasAuthorship W2087799854A5057805790 @default.
• W2087799854 hasAuthorship W2087799854A5071756138 @default.
• W2087799854 hasConcept C108636557 @default.
• W2087799854 hasConcept C11960822 @default.
• W2087799854 hasConcept C148125776 @default.
• W2087799854 hasConcept C153911025 @default.
• W2087799854 hasConcept C185592680 @default.
• W2087799854 hasConcept C203014093 @default.
• W2087799854 hasConcept C2776090121 @default.
• W2087799854 hasConcept C37686147 @default.
• W2087799854 hasConcept C86803240 @default.
• W2087799854 hasConcept C8891405 @default.
• W2087799854 hasConcept C95444343 @default.
• W2087799854 hasConceptScore W2087799854C108636557 @default.
• W2087799854 hasConceptScore W2087799854C11960822 @default.
• W2087799854 hasConceptScore W2087799854C148125776 @default.
• W2087799854 hasConceptScore W2087799854C153911025 @default.
• W2087799854 hasConceptScore W2087799854C185592680 @default.
• W2087799854 hasConceptScore W2087799854C203014093 @default.
• W2087799854 hasConceptScore W2087799854C2776090121 @default.
• W2087799854 hasConceptScore W2087799854C37686147 @default.
• W2087799854 hasConceptScore W2087799854C86803240 @default.
• W2087799854 hasConceptScore W2087799854C8891405 @default.
• W2087799854 hasConceptScore W2087799854C95444343 @default.
• W2087799854 hasIssue "2" @default.
• W2087799854 hasLocation W20877998541 @default.
• W2087799854 hasLocation W20877998542 @default.
• W2087799854 hasOpenAccess W2087799854 @default.

• next