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- W2087819660 abstract "Background: Resistance to conventional antibiotics has increased the need for novel agents with antibacterial activity. Herbs used in traditional Chinese medicine were tested for antibacterial properties both alone and in combination with antibiotics. Method: Powdered herbs were diluted in Mueller-Hinton (MH) agar for determination of the MIC of the herb against strains of S. aureus. Strains included penicillin resistant, multi-drug resistant methicillin-sensitive, methicillin-resistant strains including all SCCmec cassette types, and vancomycin intermediate resistant (VISA) strains. In addition, herb-containing agar was used for disc diffusion sensitivity testing of a range of antibiotics. The zone size on the herb-containing agar was compared to that obtained on unsupplemented MH. Results: Rhizoma coptidis at a concentration of 1% consistently inhibited the growth of all strains. Some strains of MRSA and VISA were inhibited by concentrations as low as 0.2%. Radix scutellariae inhibited growth of all strains at 0.8%. Results for Herba andrographitis and Cortex phellodendri varied greatly between strains. Combinations of Radix, Rhizoma or Cortex at concentrations of 0.1%, which was not itself inhibitory, with beta lactam antibiotics did lead to increased zone sizes for penicillin, oxacillin, and cefoxitin in penicillin-resistant strains, reversing resistance to penicillin to sensitivity in 3/6 strains tested. Methicillin resistance however was not reversed and there were only limited increases in penicillin and cefoxitin zones sizes in MRSA. Combination of the herbs with linezolid led to substantial increases in zone size (from 30 to 40 mm) in VISA strains. Conclusion: At concentrations tested, the herbs appear to interfere with beta-lactamase-associated resistance and to enhance linezolid susceptibility of VISA. VISA strains were inhibited by very low concentrations of Radix and Rhizoma. These findings suggest that use of these herbs in combination with conventional antibiotics may reverse penicillin resistance and enhance effects of other antibiotics especially with respect to VISA." @default.
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- W2087819660 date "2008-12-01" @default.
- W2087819660 modified "2023-10-05" @default.
- W2087819660 title "Antibacterial and Synergistic Effects of Extracts of Chinese Traditional Herbs Against Staphylococcus Aureus" @default.
- W2087819660 doi "https://doi.org/10.1016/j.ijid.2008.05.728" @default.
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