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• W2087851403 abstract "The objective of this work was to study the coating process of diclofenac sodium pellets, with the commercial aqueous coating suspension for enteric release – Acryl-Eze® MP, in a fluid bed coater with a Wurster insert. Coating experiments were performed following a 22 factorial design to determine the influence of process variables on coating performance, measured by the two response variables: efficiency (η%) and agglomeration index (magg%). Both response variables were found to be affected by inlet temperature and suspension flow rate with a 95% confidence level. This work also studied the release of diclofenac sodium coated and uncoated pellets in HCl 0.1 N and pH 6.8 phosphate buffer media. Results showed that the release of diclofenac sodium during the buffer stage was affected by the prior exposure to the HCl 0.1 N medium and a polymer weight gain above 9.7% (2.7 mg/cm2), was needed to modify the release in such a way that it remained below 10% for the first 120 min in HCl 0.1 N and above 75% in pH 6.8 for the next 45 min. Neither the drug content nor the release profiles were significantly affected by storage at 40 °C and 75% relative humidity." @default.
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• W2087851403 date "2013-05-01" @default.
• W2087851403 modified "2023-10-03" @default.
• W2087851403 title "Enteric coating process of diclofenac sodium pellets in a fluid bed coater with a wurster insert: Influence of process variables on coating performance and release profile" @default.
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• W2087851403 doi "https://doi.org/10.1016/j.apt.2012.12.003" @default.
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