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- W2087863311 abstract "To describe outcome in dogs with insufficient bone healing treated with recombinant human bone morphogenetic protein-2 (rhBMP-2).Retrospective study.Four dogs clinically affected with delayed union or nonunion bone healing.Medical records were reviewed for signalment, clinical problem, treatment, and outcome.Four dogs that had delayed- or nonunion of bone fracture, osteotomy, or arthrodesis were treated with either minimally invasive, fluoroscopically guided, percutaneous administration or direct surgical application of rhBMP-2. Doses used ranged from 0.2 to 1.6 mg of rhBMP-2. In 3 dogs, a calcium phosphate matrix (CPM) carrier was used whereas in 1 dog commercially prepared rhBMP-2 impregnated in an absorbable collagen sponge (INFUSE Bone Graft) was used. This latter dog had osteomyelitis associated with implant infection before rhBMP-2 administration. Rapid radiographic union was noted in all dogs with excellent long-term outcome. Adverse effects were minimal and included transient worsening of lameness after percutaneous administration of rhBMP-2 in 2 dogs.rhBMP-2 stimulated rapid bone formation at delayed- or nonunion sites resulting in radiographic bone union with minimal adverse effects and excellent long-term outcome in 4 dogs.Direct intraoperative administration or fluoroscopically guided, minimally invasive delivery of rhBMP-2 may be an effective treatment modality for bone delayed- or nonunions and could potentially be used to stimulate new bone production in a variety of orthopedic surgical conditions in dogs." @default.
- W2087863311 created "2016-06-24" @default.
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- W2087863311 date "2007-02-01" @default.
- W2087863311 modified "2023-10-18" @default.
- W2087863311 title "Clinical Application of Recombinant Human Bone Morphogenetic Protein-2 in 4 Dogs" @default.
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- W2087863311 doi "https://doi.org/10.1111/j.1532-950x.2007.00245.x" @default.
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