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• W2087863396 abstract "Numerous recent findings indicate the involvement of a neuroinflammatory reaction in the neurodegeneration in idiopathic Parkinson's disease (PD). We examined 29 consecutive patients with PD, ages 54–84 years, most of whom were moderately impaired (median UPDRS 19; Hoehn–Yahr 3; MMSE 28). A series of serum biomarkers were investigated, and their levels were correlated with the degree of the motor and cognitive impairment. There were no abnormalities of IL-6, acute phase proteins (C-reactive protein, serum amyloid A, alpha 1-antitrypsin, orosomucoid, ceruloplasmin, alpha 2-macroglobulin, transferrin, prealbumin) and factors of the complement system (C1q, C1-INH, C3, C4). A decrease in Mannan-binding lectin (MBL) levels was observed in six patients; an elevation of tumor necrosis factor-alpha (TNF-alpha) was found in 12 patients. No statistically significant correlation was found between the patient's clinical state (neuropsychologic and motor, as expressed by UPDRS III, Hoehn–Yahr, and MMSE) and the immunomarker changes. Our results indicate that the inflammatory process may be reflected in the serum; nevertheless, further research is needed to elucidate the possible clinical implications." @default.
• W2087863396 created "2016-06-24" @default.
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• W2087863396 date "2009-05-01" @default.
• W2087863396 modified "2023-09-30" @default.
• W2087863396 title "Serum inflammatory biomarkers in Parkinson's disease" @default.
• W2087863396 cites W2003870617 @default.
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• W2087863396 doi "https://doi.org/10.1016/j.parkreldis.2008.05.014" @default.
• W2087863396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18672391" @default.
• W2087863396 hasPublicationYear "2009" @default.
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