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- W2087863553 abstract "Abstract Purpose To evaluate single‐voxel proton magnetic resonance spectroscopy (SV‐MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. Materials and Methods Twenty HIV‐positive (HIV+) individuals underwent SV‐MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. Results HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV‐MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N‐acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. Conclusion SV‐MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV‐MRS measures mI, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes. J. Magn. Reson. Imaging 2005;21:325–333. © 2005 Wiley‐Liss, Inc." @default.
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- W2087863553 date "2005-03-18" @default.
- W2087863553 modified "2023-10-17" @default.
- W2087863553 title "A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia" @default.
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- W2087863553 doi "https://doi.org/10.1002/jmri.20272" @default.
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