FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087869013> ?p ?o ?g. }

• W2087869013 endingPage "886" @default.
• W2087869013 startingPage "879" @default.
• W2087869013 abstract "Epithelial-mesenchymal-transition (EMT) is a critical step in tumor invasion and metastasis, while its fate is mainly defined by the balanced expression between the miR-200 family and ZEB transcription factors. In this study, we observed a reciprocal correlation between miR-200c/mir-141 and ZEB1, as well as between ZEB2 and E-cadherin expression in a panel of 13 head and neck squamous cell carcinoma (HNSCC) cell lines. We also confirmed that the enforced expression of miR-200c and miR-141 significantly reduced the migration capacity of HNSCC cells. Accordingly, the enforced expression of miR-200c and mir-141 resulted in a significant upregulation in E-cadherin expression, contrary to the significant downregulation in ZEB1 expression in 3 cell lines (UTSCC-24A, UTSCC-24B and UTSCC-6A cells). Another pair of cell lines, UTSCC-60A and UTSCC‑ 60B failed to show a significant change in the expression of E-cadherin or ZEB1/ZEB2 during the enforced expression of miR-200c/miR-141. To address the issue, we focused on the hypermethylation status of the ZEB1/2 promoters, which have both been shown to include wide CpG islands. We observed a marked upregulation in both ZEB1 and ZEB2 mRNA expression following treatment with a demethylating agent in both pairs of UTSCC cell lines. In conclusion, our findings confirm the existence of a reciprocal correlation between the mir-200 family and the ZEB family, and demonstrate the role of the miR-200 family in EMT, as well as in the migration and invasion ability of HNSCC cells. Furthermore, our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis." @default.
• W2087869013 created "2016-06-24" @default.
• W2087869013 creator A5000572116 @default.
• W2087869013 creator A5005431176 @default.
• W2087869013 creator A5014590544 @default.
• W2087869013 creator A5038245920 @default.
• W2087869013 creator A5047381815 @default.
• W2087869013 creator A5064193017 @default.
• W2087869013 creator A5077755212 @default.
• W2087869013 date "2014-01-14" @default.
• W2087869013 modified "2023-10-01" @default.
• W2087869013 title "Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma" @default.
• W2087869013 cites W1974696926 @default.
• W2087869013 cites W1976324983 @default.
• W2087869013 cites W1980244442 @default.
• W2087869013 cites W1983991097 @default.
• W2087869013 cites W1999480352 @default.
• W2087869013 cites W2014085481 @default.
• W2087869013 cites W2017714432 @default.
• W2087869013 cites W2049048085 @default.
• W2087869013 cites W2071847134 @default.
• W2087869013 cites W2091996935 @default.
• W2087869013 cites W2097642044 @default.
• W2087869013 cites W2101136328 @default.
• W2087869013 cites W2105053318 @default.
• W2087869013 cites W2106958499 @default.
• W2087869013 cites W2107277218 @default.
• W2087869013 cites W2110773510 @default.
• W2087869013 cites W2112192177 @default.
• W2087869013 cites W2118556537 @default.
• W2087869013 cites W2124588967 @default.
• W2087869013 cites W2125120607 @default.
• W2087869013 cites W2137376905 @default.
• W2087869013 cites W2138885372 @default.
• W2087869013 doi "https://doi.org/10.3892/ijmm.2014.1625" @default.
• W2087869013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24424572" @default.
• W2087869013 hasPublicationYear "2014" @default.
• W2087869013 type Work @default.
• W2087869013 sameAs 2087869013 @default.
• W2087869013 citedByCount "68" @default.
• W2087869013 countsByYear W20878690132014 @default.
• W2087869013 countsByYear W20878690132015 @default.
• W2087869013 countsByYear W20878690132016 @default.
• W2087869013 countsByYear W20878690132017 @default.
• W2087869013 countsByYear W20878690132018 @default.
• W2087869013 countsByYear W20878690132019 @default.
• W2087869013 countsByYear W20878690132020 @default.
• W2087869013 countsByYear W20878690132021 @default.
• W2087869013 countsByYear W20878690132022 @default.
• W2087869013 countsByYear W20878690132023 @default.
• W2087869013 crossrefType "journal-article" @default.
• W2087869013 hasAuthorship W2087869013A5000572116 @default.
• W2087869013 hasAuthorship W2087869013A5005431176 @default.
• W2087869013 hasAuthorship W2087869013A5014590544 @default.
• W2087869013 hasAuthorship W2087869013A5038245920 @default.
• W2087869013 hasAuthorship W2087869013A5047381815 @default.
• W2087869013 hasAuthorship W2087869013A5064193017 @default.
• W2087869013 hasAuthorship W2087869013A5077755212 @default.
• W2087869013 hasBestOaLocation W20878690131 @default.
• W2087869013 hasConcept C104317684 @default.
• W2087869013 hasConcept C121608353 @default.
• W2087869013 hasConcept C127561419 @default.
• W2087869013 hasConcept C145059251 @default.
• W2087869013 hasConcept C1491633281 @default.
• W2087869013 hasConcept C2776530083 @default.
• W2087869013 hasConcept C2776833033 @default.
• W2087869013 hasConcept C2779013556 @default.
• W2087869013 hasConcept C2781018059 @default.
• W2087869013 hasConcept C29537977 @default.
• W2087869013 hasConcept C502942594 @default.
• W2087869013 hasConcept C54355233 @default.
• W2087869013 hasConcept C76419328 @default.
• W2087869013 hasConcept C81885089 @default.
• W2087869013 hasConcept C86803240 @default.
• W2087869013 hasConceptScore W2087869013C104317684 @default.
• W2087869013 hasConceptScore W2087869013C121608353 @default.
• W2087869013 hasConceptScore W2087869013C127561419 @default.
• W2087869013 hasConceptScore W2087869013C145059251 @default.
• W2087869013 hasConceptScore W2087869013C1491633281 @default.
• W2087869013 hasConceptScore W2087869013C2776530083 @default.
• W2087869013 hasConceptScore W2087869013C2776833033 @default.
• W2087869013 hasConceptScore W2087869013C2779013556 @default.
• W2087869013 hasConceptScore W2087869013C2781018059 @default.
• W2087869013 hasConceptScore W2087869013C29537977 @default.
• W2087869013 hasConceptScore W2087869013C502942594 @default.
• W2087869013 hasConceptScore W2087869013C54355233 @default.
• W2087869013 hasConceptScore W2087869013C76419328 @default.
• W2087869013 hasConceptScore W2087869013C81885089 @default.
• W2087869013 hasConceptScore W2087869013C86803240 @default.
• W2087869013 hasIssue "4" @default.
• W2087869013 hasLocation W20878690131 @default.
• W2087869013 hasLocation W20878690132 @default.
• W2087869013 hasOpenAccess W2087869013 @default.
• W2087869013 hasPrimaryLocation W20878690131 @default.
• W2087869013 hasRelatedWork W2150002449 @default.
• W2087869013 hasRelatedWork W2417073627 @default.
• W2087869013 hasRelatedWork W2529723636 @default.
• W2087869013 hasRelatedWork W2580637054 @default.

• next