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- W2087879789 abstract "The present study investigated the roles of the opioid-receptor-like (ORL1) receptor and its endogenous ligand nociceptin on nociception in the spinal cord of rats. Intrathecal administration of 10 nmol of nociceptin produced significant increases in hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulation. There were no significant changes of average maximum angles in inclined plane tests after intrathecal injection of 10 nmol of nociceptin in rats. The intrathecal nociceptin-induced increases in HWL were antagonized by intrathecal administration of (Nphe1)Nociceptin(1–13)-NH2, a selective antagonist of ORL1 receptor, in a dose-dependent manner. The results demonstrated that ORL1 receptor is involved in the nociceptin-induced anti-nociceptive effect in the spinal cord of rats." @default.
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- W2087879789 date "2001-09-01" @default.
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- W2087879789 title "Blockade effects of (Nphe1)Nociceptin(1–13)-NH2 on anti-nociception induced by intrathecal administration of nociceptin in rats" @default.
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- W2087879789 doi "https://doi.org/10.1016/s0167-0115(01)00263-4" @default.
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