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• W2087883189 abstract "Abstract Although bioprosthetic heart valves (BHV) remain the primary treatment modality for adult heart valve replacement, continued problems with durability remain. Several studies have implicated flexure as a major damage mode in porcine‐derived heterograft biomaterials used in BHV fabrication. Although conventional accelerated wear testing can provide valuable insights into BHV damage phenomena, the constituent tissues are subjected to complex, time‐varying deformation modes (i.e., tension and flexure) that do not allow for the control of the amount, direction, and location of flexure. Thus, in this study, customized fatigue testing devices were developed to subject circumferentially oriented porcine BHV tissue strips to controlled cyclic flexural loading. By using this approach, we were able to study layer‐specific structural damage induced by cyclic flexural tensile and compressive stresses alone. Cycle levels of 10 × 10 6 , 25 × 10 6 , and 50 × 10 6 were used, with resulting changes in flexural stiffness and collagen structure assessed. Results indicated that flexural rigidity was markedly reduced after only 10 × 10 6 cycles, and progressively decayed at a lower rate with cycle number thereafter. Moreover, the against‐curvature fatigue direction induced the most damage, suggesting that the ventricularis and fibrosa layers have low resistance to cyclic flexural compressive and tensile loads, respectively. The histological analyses indicated progressive collagen fiber delamination as early as 10 × 10 6 cycles but otherwise no change in gross collagen orientation. Our results underscore that porcine‐derived heterograft biomaterials are very sensitive to flexural fatigue, with delamination of the tissue layers the primary underlying mechanism. This appears to be in contrast to pericardial BHV, wherein high tensile stresses are considered to be the major cause of structural failure. These findings point toward the need for the development of chemical fixation technologies that minimize flexure‐induced damage to extend porcine heterograft biomaterial durability. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010" @default.
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• W2087883189 date "2010-02-17" @default.
• W2087883189 modified "2023-10-16" @default.
• W2087883189 title "Effects of cyclic flexural fatigue on porcine bioprosthetic heart valve heterograft biomaterials" @default.
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• W2087883189 doi "https://doi.org/10.1002/jbm.a.32659" @default.
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