FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087886925> ?p ?o ?g. }

• W2087886925 endingPage "2496" @default.
• W2087886925 startingPage "2488" @default.
• W2087886925 abstract "Cyclic nucleotide-gated (CNG) channels mediate sensory signal transduction in retinal and olfactory cells. The channels are activated by the binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus that is located at the intracellular side. The molecular events translating the ligand binding to the pore opening are still unknown. We investigated the role of the S4-S5 linker in the activation process by quantifying its interaction with other intracellular regions. To this end, we constructed chimeric channels in which the N-terminus, the S4-S5 linker, the C-linker, and the CNBD of the retinal CNGA1 subunit were systematically replaced by the respective regions of the olfactory CNGA2 subunit. Macroscopic concentration-response relations were analyzed, yielding the apparent affinity to cGMP and the Hill coefficient. The degree of functional coupling of intracellular regions in the activation gating was determined by thermodynamic double-mutant cycle analysis. We observed that all four intracellular regions, including the relatively short S4-S5 linker, are involved in controlling the apparent affinity of the channel to cGMP and, moreover, in determining the degree of cooperativity between the subunits, as derived from the Hill coefficient. The interaction energies reveal an interaction of the S4-S5 linker with both the N-terminus and the C-linker, but no interaction with the CNBD." @default.
• W2087886925 created "2016-06-24" @default.
• W2087886925 creator A5003072193 @default.
• W2087886925 creator A5008160362 @default.
• W2087886925 creator A5013747364 @default.
• W2087886925 creator A5019307928 @default.
• W2087886925 creator A5039091802 @default.
• W2087886925 creator A5049962451 @default.
• W2087886925 creator A5061725835 @default.
• W2087886925 date "2010-10-01" @default.
• W2087886925 modified "2023-10-18" @default.
• W2087886925 title "Role of the S4-S5 Linker in CNG Channel Activation" @default.
• W2087886925 cites W1482197265 @default.
• W2087886925 cites W1964565849 @default.
• W2087886925 cites W1969540269 @default.
• W2087886925 cites W1972775779 @default.
• W2087886925 cites W1984594026 @default.
• W2087886925 cites W1986171869 @default.
• W2087886925 cites W1991696056 @default.
• W2087886925 cites W1991785322 @default.
• W2087886925 cites W2004561786 @default.
• W2087886925 cites W2006307429 @default.
• W2087886925 cites W2008159862 @default.
• W2087886925 cites W2009667219 @default.
• W2087886925 cites W2011301782 @default.
• W2087886925 cites W2013348596 @default.
• W2087886925 cites W2018006181 @default.
• W2087886925 cites W2032734987 @default.
• W2087886925 cites W2034176125 @default.
• W2087886925 cites W2034934027 @default.
• W2087886925 cites W2036884791 @default.
• W2087886925 cites W2042343877 @default.
• W2087886925 cites W2044983910 @default.
• W2087886925 cites W2046763527 @default.
• W2087886925 cites W2048419229 @default.
• W2087886925 cites W2049576685 @default.
• W2087886925 cites W2053413578 @default.
• W2087886925 cites W2056476754 @default.
• W2087886925 cites W2056802499 @default.
• W2087886925 cites W2057812282 @default.
• W2087886925 cites W2063339881 @default.
• W2087886925 cites W2064734599 @default.
• W2087886925 cites W2068175022 @default.
• W2087886925 cites W2074376076 @default.
• W2087886925 cites W2082668900 @default.
• W2087886925 cites W2082789276 @default.
• W2087886925 cites W2083689768 @default.
• W2087886925 cites W2091651584 @default.
• W2087886925 cites W2097823677 @default.
• W2087886925 cites W2099391787 @default.
• W2087886925 cites W2107208446 @default.
• W2087886925 cites W2122530687 @default.
• W2087886925 cites W2123285513 @default.
• W2087886925 cites W2127019778 @default.
• W2087886925 cites W2128075979 @default.
• W2087886925 cites W2135827694 @default.
• W2087886925 cites W2148598721 @default.
• W2087886925 cites W2152065571 @default.
• W2087886925 cites W2154166729 @default.
• W2087886925 cites W2159772387 @default.
• W2087886925 cites W2167652900 @default.
• W2087886925 cites W2167689408 @default.
• W2087886925 cites W2169799159 @default.
• W2087886925 doi "https://doi.org/10.1016/j.bpj.2010.07.041" @default.
• W2087886925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2955497" @default.
• W2087886925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20959089" @default.
• W2087886925 hasPublicationYear "2010" @default.
• W2087886925 type Work @default.
• W2087886925 sameAs 2087886925 @default.
• W2087886925 citedByCount "12" @default.
• W2087886925 countsByYear W20878869252013 @default.
• W2087886925 countsByYear W20878869252014 @default.
• W2087886925 countsByYear W20878869252015 @default.
• W2087886925 countsByYear W20878869252016 @default.
• W2087886925 countsByYear W20878869252020 @default.
• W2087886925 crossrefType "journal-article" @default.
• W2087886925 hasAuthorship W2087886925A5003072193 @default.
• W2087886925 hasAuthorship W2087886925A5008160362 @default.
• W2087886925 hasAuthorship W2087886925A5013747364 @default.
• W2087886925 hasAuthorship W2087886925A5019307928 @default.
• W2087886925 hasAuthorship W2087886925A5039091802 @default.
• W2087886925 hasAuthorship W2087886925A5049962451 @default.
• W2087886925 hasAuthorship W2087886925A5061725835 @default.
• W2087886925 hasBestOaLocation W20878869251 @default.
• W2087886925 hasConcept C104317684 @default.
• W2087886925 hasConcept C107824862 @default.
• W2087886925 hasConcept C111919701 @default.
• W2087886925 hasConcept C116569031 @default.
• W2087886925 hasConcept C12554922 @default.
• W2087886925 hasConcept C131829789 @default.
• W2087886925 hasConcept C166014724 @default.
• W2087886925 hasConcept C166342909 @default.
• W2087886925 hasConcept C170493617 @default.
• W2087886925 hasConcept C185592680 @default.
• W2087886925 hasConcept C187250156 @default.
• W2087886925 hasConcept C194544171 @default.
• W2087886925 hasConcept C2778524494 @default.
• W2087886925 hasConcept C2780557392 @default.

• next