FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087892649> ?p ?o ?g. }

• W2087892649 endingPage "207" @default.
• W2087892649 startingPage "197" @default.
• W2087892649 abstract "Summary The epidemic of type 2 diabetes mellitus (T2DM) continues unabated and unless urgent steps are taken to prevent the onset of, or at the least, ameliorate the macrovascular complications, the medical as well as the socio-economic costs to the people will be insurmountable. Insulin resistance and decreased insulin secretory capacity of the beta cells are central to the onset of dysglycemia seen in T2DM. The thiazolinediones (glitazones) are a relatively new group of drugs which have been shown to help in correcting the dysglycemia by lowering the insulin resistance levels. Adequate attention has not been paid to the pleiotropic effects of these group of drugs. Leaving aside the controversy about whether insulin resistance leads to beta cell dysfunction or whether the beta cells are genetically prone to failure, the glitazones have a significant capacity to alleviate the beta cell failure and allow them to continue secreting insulin to meet the higher requirements imposed by the resistant state. Although the precise mechanisms are still being investigated, glitazones have been shown to significantly lessen the effects of glucotoxicity and lipotoxicity on the beta cell function and apoptosis. Moreover, in the present days, diabetes means much more than just glucose control. One has to take measures to prevent the cardiovascular complications and sequelae. The glitazones have a salutary effect on many of the traditional as well as the new risk factors and can help in preventing or lessening the impact of the cardiovascular consequences. They have been shown to lower the levels of atherogenic dyslipidemia, lower the blood pressure and lessen microalbuminuria, lower visceral obesity, lessen the levels of the proinflammatory and prothrombotic cytokines and adipokines as well as increase the levels of the antiatherogenic adinopectin. It decreases levels of PAI-1 and fibrinogen thereby lowering the procoagulant state and has a salutary effect on endothelial function. All these actions allow the glitazones to play a much larger role in our efforts to lower the vascular risks. Unfortunately, these beneficial actions are not widely recognized and reports of edema propensity, weight gain and hepatic toxicity do not allow the wider use of glitazones in our therapeutic armamentarium. This brief review discusses the pleiotropic effects of the glitazones and one would sincerely feel that they should be used early, in contrast to their present use as the third oral agent to be used in our management." @default.
• W2087892649 created "2016-06-24" @default.
• W2087892649 creator A5071040530 @default.
• W2087892649 creator A5077707454 @default.
• W2087892649 date "2007-09-01" @default.
• W2087892649 modified "2023-09-25" @default.
• W2087892649 title "Glitazones: Beyond glucose lowering!" @default.
• W2087892649 cites W1556459089 @default.
• W2087892649 cites W1639924204 @default.
• W2087892649 cites W1906044483 @default.
• W2087892649 cites W1951826532 @default.
• W2087892649 cites W1964716328 @default.
• W2087892649 cites W1966752541 @default.
• W2087892649 cites W1966950599 @default.
• W2087892649 cites W1968237817 @default.
• W2087892649 cites W1969014236 @default.
• W2087892649 cites W1972136146 @default.
• W2087892649 cites W1972779452 @default.
• W2087892649 cites W1974537687 @default.
• W2087892649 cites W1976942305 @default.
• W2087892649 cites W1977386411 @default.
• W2087892649 cites W1981444005 @default.
• W2087892649 cites W1981851376 @default.
• W2087892649 cites W1982811953 @default.
• W2087892649 cites W1983046008 @default.
• W2087892649 cites W1989619519 @default.
• W2087892649 cites W1991403690 @default.
• W2087892649 cites W1998420980 @default.
• W2087892649 cites W1999236387 @default.
• W2087892649 cites W2001322138 @default.
• W2087892649 cites W2006904161 @default.
• W2087892649 cites W2008288517 @default.
• W2087892649 cites W2009381728 @default.
• W2087892649 cites W2009658649 @default.
• W2087892649 cites W2015035505 @default.
• W2087892649 cites W2018135697 @default.
• W2087892649 cites W2020866326 @default.
• W2087892649 cites W2020984463 @default.
• W2087892649 cites W2021753308 @default.
• W2087892649 cites W2022809694 @default.
• W2087892649 cites W2024277700 @default.
• W2087892649 cites W2029870728 @default.
• W2087892649 cites W2030751874 @default.
• W2087892649 cites W2032485049 @default.
• W2087892649 cites W2037447341 @default.
• W2087892649 cites W2039647866 @default.
• W2087892649 cites W2043209055 @default.
• W2087892649 cites W2043566560 @default.
• W2087892649 cites W2043733677 @default.
• W2087892649 cites W2043770389 @default.
• W2087892649 cites W2044527141 @default.
• W2087892649 cites W2046044787 @default.
• W2087892649 cites W2052244174 @default.
• W2087892649 cites W2052441984 @default.
• W2087892649 cites W2061524651 @default.
• W2087892649 cites W2065501573 @default.
• W2087892649 cites W2068402092 @default.
• W2087892649 cites W2069861938 @default.
• W2087892649 cites W2072031497 @default.
• W2087892649 cites W2077149049 @default.
• W2087892649 cites W2079614274 @default.
• W2087892649 cites W2079695370 @default.
• W2087892649 cites W2081276121 @default.
• W2087892649 cites W2082393293 @default.
• W2087892649 cites W2085490648 @default.
• W2087892649 cites W2086785365 @default.
• W2087892649 cites W2093550819 @default.
• W2087892649 cites W2093926007 @default.
• W2087892649 cites W2097457805 @default.
• W2087892649 cites W2097784879 @default.
• W2087892649 cites W2098814823 @default.
• W2087892649 cites W2100419955 @default.
• W2087892649 cites W2101651570 @default.
• W2087892649 cites W2102634320 @default.
• W2087892649 cites W2106080706 @default.
• W2087892649 cites W2106762651 @default.
• W2087892649 cites W2108709856 @default.
• W2087892649 cites W2113328569 @default.
• W2087892649 cites W2113544353 @default.
• W2087892649 cites W2114391822 @default.
• W2087892649 cites W2115112300 @default.
• W2087892649 cites W2116822087 @default.
• W2087892649 cites W2121065969 @default.
• W2087892649 cites W2122909568 @default.
• W2087892649 cites W2127125241 @default.
• W2087892649 cites W2128899850 @default.
• W2087892649 cites W2129370381 @default.
• W2087892649 cites W2130957039 @default.
• W2087892649 cites W2132594773 @default.
• W2087892649 cites W2135568455 @default.
• W2087892649 cites W2136080583 @default.
• W2087892649 cites W2136785104 @default.
• W2087892649 cites W2138072361 @default.
• W2087892649 cites W2140254580 @default.
• W2087892649 cites W2148403865 @default.
• W2087892649 cites W2150442739 @default.
• W2087892649 cites W2152037109 @default.
• W2087892649 cites W2157222091 @default.

• next