FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087897421> ?p ?o ?g. }

• W2087897421 endingPage "e9190" @default.
• W2087897421 startingPage "e9190" @default.
• W2087897421 abstract "Platelet-activating factor (PAF) plays an important role in the pathogenesis of sepsis, and the level of plasma PAF acetylhydrolase (pPAF-AH), which inactivates PAF, decreases in sepsis patients except for the sepsis caused by severe leptospirosis. Usually, increase of pPAF-AH activity was observed in lipopolysaccharide (LPS)-induced Syrian hamster and rat sepsis models, while contradictory effects were reported for mouse model in different studies. Here, we demonstrated the in vivo effects of LPS upon the change of pPAF-AH activity in C57BL/6 mice and Mongolian gerbils. After LPS-treatment, the clinical manifestations of Mongolian gerbil model were apparently similar to that of C57BL/6 mouse sepsis model. The pPAF-AH activity increased in C57BL/6 mice after LPS induction, but decreased in Mongolian gerbils, which was similar to that of the human sepsis. It thus suggests that among the LPS-induced rodent sepsis models, only Mongolian gerbil could be used for the study of pPAF-AH related to the pathogenesis of human sepsis. Proper application of this model might enable people to clarify the underline mechanism accounted for the contradictory results between the phase II and phase III clinical trials for the administration of recombinant human pPAF-AH in the sepsis therapy." @default.
• W2087897421 created "2016-06-24" @default.
• W2087897421 creator A5032981547 @default.
• W2087897421 creator A5049290197 @default.
• W2087897421 creator A5050388216 @default.
• W2087897421 creator A5062050277 @default.
• W2087897421 creator A5062097440 @default.
• W2087897421 creator A5074391954 @default.
• W2087897421 creator A5077173117 @default.
• W2087897421 date "2010-02-12" @default.
• W2087897421 modified "2023-10-11" @default.
• W2087897421 title "Decrease of Plasma Platelet-Activating Factor Acetylhydrolase Activity in Lipopolysaccharide Induced Mongolian Gerbil Sepsis Model" @default.
• W2087897421 cites W1965669732 @default.
• W2087897421 cites W1969664133 @default.
• W2087897421 cites W1980123081 @default.
• W2087897421 cites W1980324165 @default.
• W2087897421 cites W1997397222 @default.
• W2087897421 cites W2005984994 @default.
• W2087897421 cites W2009400027 @default.
• W2087897421 cites W2027161938 @default.
• W2087897421 cites W2027752637 @default.
• W2087897421 cites W2035116744 @default.
• W2087897421 cites W2038192573 @default.
• W2087897421 cites W2048462883 @default.
• W2087897421 cites W2050036363 @default.
• W2087897421 cites W2053554593 @default.
• W2087897421 cites W2062616792 @default.
• W2087897421 cites W2070862753 @default.
• W2087897421 cites W2094943998 @default.
• W2087897421 cites W2101720275 @default.
• W2087897421 cites W2153912688 @default.
• W2087897421 cites W2157801459 @default.
• W2087897421 cites W2281191832 @default.
• W2087897421 cites W2783888699 @default.
• W2087897421 doi "https://doi.org/10.1371/journal.pone.0009190" @default.
• W2087897421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2820537" @default.
• W2087897421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20169191" @default.
• W2087897421 hasPublicationYear "2010" @default.
• W2087897421 type Work @default.
• W2087897421 sameAs 2087897421 @default.
• W2087897421 citedByCount "11" @default.
• W2087897421 countsByYear W20878974212012 @default.
• W2087897421 countsByYear W20878974212014 @default.
• W2087897421 countsByYear W20878974212015 @default.
• W2087897421 countsByYear W20878974212019 @default.
• W2087897421 crossrefType "journal-article" @default.
• W2087897421 hasAuthorship W2087897421A5032981547 @default.
• W2087897421 hasAuthorship W2087897421A5049290197 @default.
• W2087897421 hasAuthorship W2087897421A5050388216 @default.
• W2087897421 hasAuthorship W2087897421A5062050277 @default.
• W2087897421 hasAuthorship W2087897421A5062097440 @default.
• W2087897421 hasAuthorship W2087897421A5074391954 @default.
• W2087897421 hasAuthorship W2087897421A5077173117 @default.
• W2087897421 hasBestOaLocation W20878974211 @default.
• W2087897421 hasConcept C126322002 @default.
• W2087897421 hasConcept C150903083 @default.
• W2087897421 hasConcept C17991360 @default.
• W2087897421 hasConcept C203014093 @default.
• W2087897421 hasConcept C207001950 @default.
• W2087897421 hasConcept C2776914184 @default.
• W2087897421 hasConcept C2778384902 @default.
• W2087897421 hasConcept C2778754761 @default.
• W2087897421 hasConcept C2779020240 @default.
• W2087897421 hasConcept C2780222073 @default.
• W2087897421 hasConcept C2780942790 @default.
• W2087897421 hasConcept C541997718 @default.
• W2087897421 hasConcept C71924100 @default.
• W2087897421 hasConcept C86803240 @default.
• W2087897421 hasConcept C98274493 @default.
• W2087897421 hasConceptScore W2087897421C126322002 @default.
• W2087897421 hasConceptScore W2087897421C150903083 @default.
• W2087897421 hasConceptScore W2087897421C17991360 @default.
• W2087897421 hasConceptScore W2087897421C203014093 @default.
• W2087897421 hasConceptScore W2087897421C207001950 @default.
• W2087897421 hasConceptScore W2087897421C2776914184 @default.
• W2087897421 hasConceptScore W2087897421C2778384902 @default.
• W2087897421 hasConceptScore W2087897421C2778754761 @default.
• W2087897421 hasConceptScore W2087897421C2779020240 @default.
• W2087897421 hasConceptScore W2087897421C2780222073 @default.
• W2087897421 hasConceptScore W2087897421C2780942790 @default.
• W2087897421 hasConceptScore W2087897421C541997718 @default.
• W2087897421 hasConceptScore W2087897421C71924100 @default.
• W2087897421 hasConceptScore W2087897421C86803240 @default.
• W2087897421 hasConceptScore W2087897421C98274493 @default.
• W2087897421 hasIssue "2" @default.
• W2087897421 hasLocation W20878974211 @default.
• W2087897421 hasLocation W20878974212 @default.
• W2087897421 hasLocation W20878974213 @default.
• W2087897421 hasLocation W20878974214 @default.
• W2087897421 hasOpenAccess W2087897421 @default.
• W2087897421 hasPrimaryLocation W20878974211 @default.
• W2087897421 hasRelatedWork W2004283601 @default.
• W2087897421 hasRelatedWork W2052737509 @default.
• W2087897421 hasRelatedWork W2062553756 @default.
• W2087897421 hasRelatedWork W2068805684 @default.
• W2087897421 hasRelatedWork W2107907376 @default.
• W2087897421 hasRelatedWork W2119906870 @default.
• W2087897421 hasRelatedWork W2123116789 @default.

• next