Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087898315> ?p ?o ?g. }
- W2087898315 endingPage "2393" @default.
- W2087898315 startingPage "2381" @default.
- W2087898315 abstract "The presence of an effective crystal growth inhibitor in solution is desirable to prolong supersaturation since residual crystalline material in an amorphous formulation resulting from the manufacturing process or formed during storage or dissolution can potentially have a significant impact on the extent and duration of supersaturation. In this study, the effectiveness of a group of chemically diverse polymers, including several recently synthesized cellulose derivatives, on solution crystal growth of three structurally diverse compounds (celecoxib, efavirenz, and ritonavir) was quantified at different extents of supersaturation and compared. Despite the different chemical properties and structures of the model compounds, nonspecific hydrophobic drug-polymer interactions appeared to be important in determining the impact of a given polymer on crystal growth for of all these drug compounds. Specific intermolecular interactions were also found to be important for crystal growth inhibition of celecoxib and efavirenz by the hydrophilic polymer, PVPVA. These interactive forces-hydrophobicity and specific intermolecular interactions-are likely to promote adsorption of the polymer onto the surface of the crystalline drugs, thus influencing crystal growth. The effectiveness of the polymers also depended on the rate of crystallization of the drug molecules. At a similar supersaturation ratio of ∼1.2, ritonavir and celecoxib had slower normalized crystal growth rates (0.20 and 0.91 mg min(-1) m(-2), respectively), while the normalized crystal growth rate of efavirenz was significantly higher (2.97 mg min(-1) m(-2)), resulting in lower levels of crystal growth inhibition by the polymers for efavirenz." @default.
- W2087898315 created "2016-06-24" @default.
- W2087898315 creator A5042570256 @default.
- W2087898315 creator A5052442746 @default.
- W2087898315 creator A5079286251 @default.
- W2087898315 creator A5090835640 @default.
- W2087898315 date "2013-05-02" @default.
- W2087898315 modified "2023-10-17" @default.
- W2087898315 title "Impact of Polymers on Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution" @default.
- W2087898315 cites W1498305210 @default.
- W2087898315 cites W173409661 @default.
- W2087898315 cites W1963628508 @default.
- W2087898315 cites W1980607980 @default.
- W2087898315 cites W1982850799 @default.
- W2087898315 cites W1983819655 @default.
- W2087898315 cites W1986178530 @default.
- W2087898315 cites W1990663620 @default.
- W2087898315 cites W1994032164 @default.
- W2087898315 cites W1997698573 @default.
- W2087898315 cites W1997989484 @default.
- W2087898315 cites W1998154319 @default.
- W2087898315 cites W2000696385 @default.
- W2087898315 cites W2001410927 @default.
- W2087898315 cites W2011254969 @default.
- W2087898315 cites W2015345334 @default.
- W2087898315 cites W2015753821 @default.
- W2087898315 cites W2016049659 @default.
- W2087898315 cites W2017954968 @default.
- W2087898315 cites W2020405447 @default.
- W2087898315 cites W2035538063 @default.
- W2087898315 cites W2036426235 @default.
- W2087898315 cites W2036442936 @default.
- W2087898315 cites W2038837578 @default.
- W2087898315 cites W2039316284 @default.
- W2087898315 cites W2050292825 @default.
- W2087898315 cites W2053383323 @default.
- W2087898315 cites W2054756866 @default.
- W2087898315 cites W2056995570 @default.
- W2087898315 cites W2063209823 @default.
- W2087898315 cites W2065664930 @default.
- W2087898315 cites W2066847123 @default.
- W2087898315 cites W2071377118 @default.
- W2087898315 cites W2073616720 @default.
- W2087898315 cites W2079495578 @default.
- W2087898315 cites W2089298706 @default.
- W2087898315 cites W2089950832 @default.
- W2087898315 cites W2091390295 @default.
- W2087898315 cites W2098027131 @default.
- W2087898315 cites W2102726789 @default.
- W2087898315 cites W2107571168 @default.
- W2087898315 cites W2111505323 @default.
- W2087898315 cites W2129827408 @default.
- W2087898315 cites W2138178106 @default.
- W2087898315 cites W2139893082 @default.
- W2087898315 cites W2146872605 @default.
- W2087898315 cites W2155451228 @default.
- W2087898315 cites W2157471870 @default.
- W2087898315 cites W2159728014 @default.
- W2087898315 cites W2312314935 @default.
- W2087898315 cites W2327742714 @default.
- W2087898315 cites W2330536366 @default.
- W2087898315 cites W2331148779 @default.
- W2087898315 cites W2335512730 @default.
- W2087898315 cites W2476591406 @default.
- W2087898315 cites W4253714516 @default.
- W2087898315 doi "https://doi.org/10.1021/mp400029v" @default.
- W2087898315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23597294" @default.
- W2087898315 hasPublicationYear "2013" @default.
- W2087898315 type Work @default.
- W2087898315 sameAs 2087898315 @default.
- W2087898315 citedByCount "91" @default.
- W2087898315 countsByYear W20878983152013 @default.
- W2087898315 countsByYear W20878983152014 @default.
- W2087898315 countsByYear W20878983152015 @default.
- W2087898315 countsByYear W20878983152016 @default.
- W2087898315 countsByYear W20878983152017 @default.
- W2087898315 countsByYear W20878983152018 @default.
- W2087898315 countsByYear W20878983152019 @default.
- W2087898315 countsByYear W20878983152020 @default.
- W2087898315 countsByYear W20878983152021 @default.
- W2087898315 countsByYear W20878983152022 @default.
- W2087898315 countsByYear W20878983152023 @default.
- W2087898315 crossrefType "journal-article" @default.
- W2087898315 hasAuthorship W2087898315A5042570256 @default.
- W2087898315 hasAuthorship W2087898315A5052442746 @default.
- W2087898315 hasAuthorship W2087898315A5079286251 @default.
- W2087898315 hasAuthorship W2087898315A5090835640 @default.
- W2087898315 hasConcept C127413603 @default.
- W2087898315 hasConcept C142462285 @default.
- W2087898315 hasConcept C166950319 @default.
- W2087898315 hasConcept C178790620 @default.
- W2087898315 hasConcept C184651966 @default.
- W2087898315 hasConcept C185592680 @default.
- W2087898315 hasConcept C192562407 @default.
- W2087898315 hasConcept C199360897 @default.
- W2087898315 hasConcept C200447597 @default.
- W2087898315 hasConcept C203036418 @default.
- W2087898315 hasConcept C26456737 @default.