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- W2087899056 abstract "Heat inactivation has been used in an attempt to differentiate the iso-enzymes of plasma alkaline phosphatase and results of these studies are presented. Dilutions of specimens either with water or Tris buffered saline prior to heat inactivation gave different results from those obtained with undiluted plasma. Heat inactivation has not helped greatly in identifying the source of plasma alkaline phosphatase in most patients whose level is found to be elevated on the SMA 12/60 screening procedure and where no obvious clinical cause for the elevation is apparent. Elevations in plasma alkaline phosphatase may occur in a variety of clinical conditions. This enzyme is one of the variables measured on the SMA 12/60 screen in this hospital and a considerable number of unexplained high results i.e., greater than 100 International Units have occurred, often as the only abnormality. Heat inactivation has been used in an attempt to differentiate the iso-enzymes of plasma alkaline phosphatase and results of these studies are presented. Dilutions of specimens either with water or Tris buffered saline prior to heat inactivation gave different results from those obtained with undiluted plasma. Heat inactivation has not helped greatly in identifying the source of plasma alkaline phosphatase in most patients whose level is found to be elevated on the SMA 12/60 screening procedure and where no obvious clinical cause for the elevation is apparent. Elevations in plasma alkaline phosphatase may occur in a variety of clinical conditions. This enzyme is one of the variables measured on the SMA 12/60 screen in this hospital and a considerable number of unexplained high results i.e., greater than 100 International Units have occurred, often as the only abnormality." @default.
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- W2087899056 date "1974-01-01" @default.
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- W2087899056 title "Some Observations on the Heat Inactivation of Plasma Alkaline Phosphatase" @default.
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- W2087899056 doi "https://doi.org/10.3109/00313027409077153" @default.
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