FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087905904> ?p ?o ?g. }

• W2087905904 endingPage "141" @default.
• W2087905904 startingPage "133" @default.
• W2087905904 abstract "Purpose The aim of this study was to examine molecular subtype conversions in patients who underwent neoadjuvant chemotherapy (NAC) and analyze their clinical implications. Materials and Methods We included consecutive breast cancer patients who received NAC at the National Cancer Center, Korea, between August 2002 and June 2011, and had available data on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) receptor status prior to NAC. Molecular subtypes, hormone receptor (HR) status, and ER and PR Allred scores before and after NAC were compared, and the long-term outcomes were analyzed. Results Of 322 patients, 32 (9.9%) achieved a pathologic complete response after NAC. HR+/HER2– tumors tended to convert into triple negative (TN) tumors (10.3%), whereas 34.6% of TN tumors gained HR positivity to become HR+/HER2– tumors. Clinical outcomes of molecular subtype conversion groups were compared against patients who remained as HR+/HER2– throughout. The HR+/HER2– to TN group had significantly poorer recurrence-free survival (RFS) (hazard ratio, 3.54; 95% confidence interval [CI], 1.60 to 7.85) and overall survival (OS) (hazard ratio, 3.73; 95% CI, 1.34 to 10.38). Patients who remained TN throughout had the worst outcomes (for RFS: hazard ratio, 3.70; 95% CI, 1.86 to 7.36; for OS: hazard ratio, 5.85; 95% CI, 2.53 to 13.51), while those who converted from TN to HR+/HER2–showed improved comparable survival outcomes. Conclusion Molecular subtypes of breast cancers changed frequently after NAC, resulting in different tumor prognostication. Tumor subtyping should be repeated after NAC in patients with breast cancer. Key words: Breast neoplasms, Molecular subtype, Receptor status, Neoadjuvant chemotherapy" @default.
• W2087905904 created "2016-06-24" @default.
• W2087905904 creator A5034235306 @default.
• W2087905904 creator A5034928402 @default.
• W2087905904 creator A5038366277 @default.
• W2087905904 creator A5038481896 @default.
• W2087905904 creator A5043384467 @default.
• W2087905904 creator A5049160212 @default.
• W2087905904 creator A5051676656 @default.
• W2087905904 creator A5066449485 @default.
• W2087905904 creator A5075712744 @default.
• W2087905904 creator A5091720361 @default.
• W2087905904 date "2016-01-15" @default.
• W2087905904 modified "2023-10-18" @default.
• W2087905904 title "Impact of Molecular Subtype Conversion of Breast Cancers after Neoadjuvant Chemotherapy on Clinical Outcome" @default.
• W2087905904 cites W1605443560 @default.
• W2087905904 cites W1967186439 @default.
• W2087905904 cites W1982992455 @default.
• W2087905904 cites W1991307975 @default.
• W2087905904 cites W2020598525 @default.
• W2087905904 cites W2028722272 @default.
• W2087905904 cites W2030002770 @default.
• W2087905904 cites W2031042189 @default.
• W2087905904 cites W2044702943 @default.
• W2087905904 cites W2048114394 @default.
• W2087905904 cites W2050645138 @default.
• W2087905904 cites W2053074390 @default.
• W2087905904 cites W2053396193 @default.
• W2087905904 cites W2087203082 @default.
• W2087905904 cites W2092819458 @default.
• W2087905904 cites W2113242459 @default.
• W2087905904 cites W2116878267 @default.
• W2087905904 cites W2149579505 @default.
• W2087905904 cites W2154142993 @default.
• W2087905904 cites W2154240098 @default.
• W2087905904 cites W2158997529 @default.
• W2087905904 cites W2161426850 @default.
• W2087905904 cites W2161977537 @default.
• W2087905904 cites W2163318274 @default.
• W2087905904 cites W2164774797 @default.
• W2087905904 cites W2171015116 @default.
• W2087905904 cites W4241664300 @default.
• W2087905904 doi "https://doi.org/10.4143/crt.2014.262" @default.
• W2087905904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4720061" @default.
• W2087905904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25865655" @default.
• W2087905904 hasPublicationYear "2016" @default.
• W2087905904 type Work @default.
• W2087905904 sameAs 2087905904 @default.
• W2087905904 citedByCount "33" @default.
• W2087905904 countsByYear W20879059042015 @default.
• W2087905904 countsByYear W20879059042016 @default.
• W2087905904 countsByYear W20879059042018 @default.
• W2087905904 countsByYear W20879059042019 @default.
• W2087905904 countsByYear W20879059042020 @default.
• W2087905904 countsByYear W20879059042021 @default.
• W2087905904 countsByYear W20879059042022 @default.
• W2087905904 countsByYear W20879059042023 @default.
• W2087905904 crossrefType "journal-article" @default.
• W2087905904 hasAuthorship W2087905904A5034235306 @default.
• W2087905904 hasAuthorship W2087905904A5034928402 @default.
• W2087905904 hasAuthorship W2087905904A5038366277 @default.
• W2087905904 hasAuthorship W2087905904A5038481896 @default.
• W2087905904 hasAuthorship W2087905904A5043384467 @default.
• W2087905904 hasAuthorship W2087905904A5049160212 @default.
• W2087905904 hasAuthorship W2087905904A5051676656 @default.
• W2087905904 hasAuthorship W2087905904A5066449485 @default.
• W2087905904 hasAuthorship W2087905904A5075712744 @default.
• W2087905904 hasAuthorship W2087905904A5091720361 @default.
• W2087905904 hasBestOaLocation W20879059041 @default.
• W2087905904 hasConcept C121608353 @default.
• W2087905904 hasConcept C126322002 @default.
• W2087905904 hasConcept C143998085 @default.
• W2087905904 hasConcept C207103383 @default.
• W2087905904 hasConcept C23589133 @default.
• W2087905904 hasConcept C2776694085 @default.
• W2087905904 hasConcept C2908728163 @default.
• W2087905904 hasConcept C44249647 @default.
• W2087905904 hasConcept C50382708 @default.
• W2087905904 hasConcept C530470458 @default.
• W2087905904 hasConcept C71924100 @default.
• W2087905904 hasConcept C84606932 @default.
• W2087905904 hasConcept C98717036 @default.
• W2087905904 hasConceptScore W2087905904C121608353 @default.
• W2087905904 hasConceptScore W2087905904C126322002 @default.
• W2087905904 hasConceptScore W2087905904C143998085 @default.
• W2087905904 hasConceptScore W2087905904C207103383 @default.
• W2087905904 hasConceptScore W2087905904C23589133 @default.
• W2087905904 hasConceptScore W2087905904C2776694085 @default.
• W2087905904 hasConceptScore W2087905904C2908728163 @default.
• W2087905904 hasConceptScore W2087905904C44249647 @default.
• W2087905904 hasConceptScore W2087905904C50382708 @default.
• W2087905904 hasConceptScore W2087905904C530470458 @default.
• W2087905904 hasConceptScore W2087905904C71924100 @default.
• W2087905904 hasConceptScore W2087905904C84606932 @default.
• W2087905904 hasConceptScore W2087905904C98717036 @default.
• W2087905904 hasFunder F4320322052 @default.
• W2087905904 hasIssue "1" @default.
• W2087905904 hasLocation W20879059041 @default.

• next