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- W2087908726 abstract "Four steroidal ketones were isolated from the holdfast of cultivated Laminaria japonica. The structures were characterized as ergosta-4, 24(28)-diene-3-one (1), ergosta-4, 24(28)-diene-3, 6-dione (2), stigmasta-4, 24(28)-diene-3-one (3) and stigmasta-4, 24(28)-diene-3, 6-dione (4), by spectral data. Compounds 2 and 4 were shown to be cytotoxic against the MCF-7 human breast cancer cell, and the growth of MCF-7 was inhibited by 96% and 79%, respectively, at 10 μg/mL. It is the first report on the isolation of cytotoxic steroidal ketones from the kelp in the genus of Laminaria." @default.
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- W2087908726 date "2003-06-01" @default.
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- W2087908726 title "Cytotoxic constituents in the holdfast of cultivated Laminaria japonica" @default.
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- W2087908726 doi "https://doi.org/10.1046/j.1444-2906.2003.00667.x" @default.
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