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- W2087923229 abstract "Significance MHC class I molecules select and present a limited set of peptides from a broad repertoire provided by TAP. How MHC class I makes this selection is unclear. We show that MHC class I H-2K b molecules initially bind many peptides because of highly flexible binding pockets. Peptide binding is followed by a selection step wherein a large fraction of these peptides is released, leaving the canonical peptides for presentation. The peptide presentation has a remarkable temperature dependency and explains the low-affinity peptides found associated to MHC class I molecules in cells cultured at low temperature. Our data suggest that MHC class I goes through rounds of considering and rejecting peptides until peptides with high affinity are acquired for presentation." @default.
- W2087923229 created "2016-06-24" @default.
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- W2087923229 date "2015-01-20" @default.
- W2087923229 modified "2023-10-15" @default.
- W2087923229 title "The first step of peptide selection in antigen presentation by MHC class I molecules" @default.
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- W2087923229 doi "https://doi.org/10.1073/pnas.1416543112" @default.
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