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- W2087926339 abstract "Abstract We previously reported that pyrroline-5-carboxylate (PC), the intermediate in the interconversions of proline, ornithine and glutamate markedly stimulates hexosemonophosphate-pentose pathway activity in human erythrocytes. The stimulation is mediated by pyrroline-5-carboxylate reductase which generates NADP+ accompanying the conversion of pyrroline-5-carboxylate to proline. We now report that the previously demonstrated effect of pyrroline-5-carboxylate on glucose oxidation through the hexose-monophosphate-pentose pathway is accompanied by increased phosphoribosyl-pyrophosphate production and increased formation of nucleotides via the salvage pathway. The demonstrated effect of pyrroline-5-carboxylate on purine processing may provide a regulatory link between amino acid and nucleotide metabolism." @default.
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- W2087926339 date "1981-11-01" @default.
- W2087926339 modified "2023-09-27" @default.
- W2087926339 title "The stimulation of purine nucleotide production by pyrroline-5-carboxylic acid in human erythrocytes" @default.
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- W2087926339 doi "https://doi.org/10.1016/0006-291x(81)91668-5" @default.
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