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- W2087931233 abstract "Interleukin 7 (IL-7), originally described as a B cell growth factor, has recently been found to play a critical role in T and B lymphocyte development and function. This study evaluated the effects of IL-7 on myelin specific T cells. IL-7 strongly enhanced proliferation of proteolipid protein (PLP) 139-151 specific T cells in association with elevated secretion of the T cell growth factor IL-2. Co-stimulation with IL-7 preferentially increased the levels of pro-inflammatory cytokines secreted by PLP 139-151 specific T cells and adoptive transfer of these cells into naive recipients induced a profound enhancement of experimental autoimmune encephalomyelitis, an animal model for the human disease multiple sclerosis. These results suggest that IL-7 may be a critical co-stimulatory factor that enhances the extrathymic expansion of inflammatory T cells and may play an important role in the pathogenesis of a number of inflammatory autoimmune disorders." @default.
- W2087931233 created "2016-06-24" @default.
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- W2087931233 date "2000-04-01" @default.
- W2087931233 modified "2023-10-18" @default.
- W2087931233 title "INTERLEUKIN 7 IS A POTENT CO-STIMULATOR OF MYELIN SPECIFIC T CELLS THAT ENHANCES THE ADOPTIVE TRANSFER OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS" @default.
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- W2087931233 doi "https://doi.org/10.1006/cyto.1999.0564" @default.
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