FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087942482> ?p ?o ?g. }

• W2087942482 endingPage "235" @default.
• W2087942482 startingPage "231" @default.
• W2087942482 abstract "Purpose of review Multiple sclerosis (MS) is the most common chronic inflammatory neurological disease. Despite major advances the aetiology of this disease it is still not completely understood. In the post-genome era, advances in global screening technologies offer an opportunity to accelerate the search of new pathological pathways and to identify new therapeutic targets. Some recent publications using novel global screening methods at the genome, transcriptome, proteome and metabolome levels are discussed. Recent findings The genetic association of susceptibility to MS with loci outside the MHC has been reconfirmed. Evidence of parent-of-origin and seasonal effects on disease susceptibility add further complexity to the genetics of MS. The search for MS susceptibility genes continues using the candidate-gene approach as well as large-scale single-nucleotide-polymorphism association studies and novel cross-species synteny analysis. Genome-wide expression profiling using microarrays produced numerous therapeutic targets and is progressing towards profiling of rare cells. Advances in classical proteomics methods paved the way to new initiatives aiming at determining the proteome of the nervous system in normal and diseased states. Although progress is still slow, array-based methods are making an impact on the MS field. Summary The complexity of MS is clearly reflected in the latest findings using global profiling methods. Nevertheless, these new technologies are confirming some of the basic aspects of the disease pathophysiology, i.e. its polygenicity, the central role of neuroinflammation and the emerging neurodenegerative processes. These data are primarily the results of genomic approaches, yet promising attempts are also made using proteomics and metabolomics." @default.
• W2087942482 created "2016-06-24" @default.
• W2087942482 creator A5030928316 @default.
• W2087942482 creator A5062220148 @default.
• W2087942482 date "2005-06-01" @default.
• W2087942482 modified "2023-09-27" @default.
• W2087942482 title "Genomics, proteomics, metabolomics: what is in a word for multiple sclerosis?" @default.
• W2087942482 cites W1530467972 @default.
• W2087942482 cites W1606977516 @default.
• W2087942482 cites W1966060799 @default.
• W2087942482 cites W1973411765 @default.
• W2087942482 cites W1975171491 @default.
• W2087942482 cites W1987057401 @default.
• W2087942482 cites W2002654969 @default.
• W2087942482 cites W2002896714 @default.
• W2087942482 cites W2003407908 @default.
• W2087942482 cites W2006472049 @default.
• W2087942482 cites W2010086107 @default.
• W2087942482 cites W2022421213 @default.
• W2087942482 cites W2031007823 @default.
• W2087942482 cites W2034860726 @default.
• W2087942482 cites W2036395605 @default.
• W2087942482 cites W2041071307 @default.
• W2087942482 cites W2041080239 @default.
• W2087942482 cites W2049838235 @default.
• W2087942482 cites W2063296711 @default.
• W2087942482 cites W2067245109 @default.
• W2087942482 cites W2076598308 @default.
• W2087942482 cites W2078442577 @default.
• W2087942482 cites W2081352868 @default.
• W2087942482 cites W2083485745 @default.
• W2087942482 cites W2101152074 @default.
• W2087942482 cites W2102669488 @default.
• W2087942482 cites W2105753150 @default.
• W2087942482 cites W2105928352 @default.
• W2087942482 cites W2106887702 @default.
• W2087942482 cites W2110633552 @default.
• W2087942482 cites W2119412335 @default.
• W2087942482 cites W2121574075 @default.
• W2087942482 cites W2124545683 @default.
• W2087942482 cites W2127573941 @default.
• W2087942482 cites W2131629478 @default.
• W2087942482 cites W2132873607 @default.
• W2087942482 cites W2134696758 @default.
• W2087942482 cites W2135940831 @default.
• W2087942482 cites W2136059495 @default.
• W2087942482 cites W2139846209 @default.
• W2087942482 cites W2143901932 @default.
• W2087942482 cites W2146843966 @default.
• W2087942482 cites W2150466754 @default.
• W2087942482 cites W2155081037 @default.
• W2087942482 cites W2157075174 @default.
• W2087942482 cites W2160243675 @default.
• W2087942482 cites W2162655753 @default.
• W2087942482 cites W2221425513 @default.
• W2087942482 doi "https://doi.org/10.1097/01.wco.0000169738.06664.3b" @default.
• W2087942482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15891405" @default.
• W2087942482 hasPublicationYear "2005" @default.
• W2087942482 type Work @default.
• W2087942482 sameAs 2087942482 @default.
• W2087942482 citedByCount "38" @default.
• W2087942482 countsByYear W20879424822012 @default.
• W2087942482 countsByYear W20879424822013 @default.
• W2087942482 countsByYear W20879424822014 @default.
• W2087942482 countsByYear W20879424822016 @default.
• W2087942482 countsByYear W20879424822017 @default.
• W2087942482 countsByYear W20879424822018 @default.
• W2087942482 countsByYear W20879424822019 @default.
• W2087942482 countsByYear W20879424822020 @default.
• W2087942482 countsByYear W20879424822021 @default.
• W2087942482 countsByYear W20879424822022 @default.
• W2087942482 crossrefType "journal-article" @default.
• W2087942482 hasAuthorship W2087942482A5030928316 @default.
• W2087942482 hasAuthorship W2087942482A5062220148 @default.
• W2087942482 hasConcept C104317684 @default.
• W2087942482 hasConcept C104397665 @default.
• W2087942482 hasConcept C141231307 @default.
• W2087942482 hasConcept C142724271 @default.
• W2087942482 hasConcept C150194340 @default.
• W2087942482 hasConcept C162317418 @default.
• W2087942482 hasConcept C189206191 @default.
• W2087942482 hasConcept C203014093 @default.
• W2087942482 hasConcept C2779134260 @default.
• W2087942482 hasConcept C2780640218 @default.
• W2087942482 hasConcept C46111723 @default.
• W2087942482 hasConcept C54355233 @default.
• W2087942482 hasConcept C60644358 @default.
• W2087942482 hasConcept C70721500 @default.
• W2087942482 hasConcept C71924100 @default.
• W2087942482 hasConcept C86803240 @default.
• W2087942482 hasConcept C95371953 @default.
• W2087942482 hasConceptScore W2087942482C104317684 @default.
• W2087942482 hasConceptScore W2087942482C104397665 @default.
• W2087942482 hasConceptScore W2087942482C141231307 @default.
• W2087942482 hasConceptScore W2087942482C142724271 @default.
• W2087942482 hasConceptScore W2087942482C150194340 @default.
• W2087942482 hasConceptScore W2087942482C162317418 @default.
• W2087942482 hasConceptScore W2087942482C189206191 @default.

• next