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• W2087949217 abstract "The thrombogenicity of beta-PL/UV-treated PPSB (factor IX concentrate) was evaluated in chimpanzees. PPSB isolated from beta-propiolactone-treated and UV-irradiated plasma was injected into chimpanzees at a dose of approximately 100 units/kg body weight. An FDA licensed PPSB preparation served as the negative control, and a preparation containing activated as well as precursor clotting factors served as the positive control. 15 minutes, 1 h, 4 h, and 24 h after the PPSB application the following parameters were determined in the chimpanzee blood: factors II, VII, IX, X, VIII, fibrinogen, AT III, thrombin coagulase, Quick value, APTT and platelet count. Neither the untreated control preparation, nor the PPSB isolated from beta-propiolactone-treated and UV-irradiated plasma, showed signs of thrombogenicity in the chimpanzee model. The positive control indicated that the chimpanzee is a suitable model for the thrombogenicity testing of activated clotting factors." @default.
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• W2087949217 date "1983-05-01" @default.
• W2087949217 modified "2023-09-25" @default.
• W2087949217 title "Evaluation of thrombogenicity of β-propiolactone/ultraviolet (β-PL/UV) treated PPSB in chimpanzees" @default.
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• W2087949217 doi "https://doi.org/10.1016/0049-3848(83)90077-4" @default.
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