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- W2087954489 abstract "ObjectiveDetermine (1) the site-associated response of articular cartilage of the equine distal metacarpal condyle to training at a young age as assessed by changes in indentation stiffness and alterations in cartilage structure and composition, and (2) relationships between indentation stiffness and indices of cartilage structure and composition.MethodExperimental animals (n=6) were trained on a track (increasing exercise to 1 km/day by 5 months); controls (n=6) were pasture-reared. Animals were euthanized at 18 months and four osteochondral samples were harvested per metacarpal condyle from dorsal–medial, dorsal–lateral, palmar–medial, and palmar–lateral aspects. Cartilage was analyzed for India ink staining (quantified as reflectance score (RS)), short-term indentation stiffness (sphere-ended, 0.4 mm diameter), thickness, and biochemical composition.ResultsCartilage structural, biochemical and biomechanical properties varied markedly with site in the joint. Sites just medial and just lateral to the sagittal ridge showed signs of early degeneration, with relatively low RS, indentation stiffness, and collagen content, and relatively high water content. Effects of exercise and side (left vs right) were not detected for any measure. Overall, indentation stiffness correlated positively with RS and collagen content, and inversely with thickness and water content.ConclusionGentle exercise-imposed mechanical stimulation did not markedly affect articular cartilage function or structure. However, the marked site-associated variation suggests that biomechanical environment can initiate degenerative changes in immature cartilage during joint growth and maturation." @default.
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- W2087954489 date "2004-10-01" @default.
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- W2087954489 title "Site- and exercise-related variation in structure and function of cartilage from equine distal metacarpal condyle" @default.
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- W2087954489 doi "https://doi.org/10.1016/j.joca.2004.07.001" @default.
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