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- W2087957210 endingPage "151" @default.
- W2087957210 startingPage "131" @default.
- W2087957210 abstract "Inefficient and inaccurate repair of DNA damage is the principal cause of DNA mutations, chromosomal aberrations, and carcinogenesis. Numerous multiple-step DNA repair pathways exist whose deployment depends on the nature of the DNA lesion. Common to all eukaryotic DNA repair pathways is the need to unravel the compacted chromatin structure to facilitate access of the repair machinery to the DNA and restoration of the original chromatin state afterward. Accordingly, our cells utilize a plethora of coordinated mechanisms to locally open up the chromatin structure to reveal the underlying DNA sequence and to orchestrate the efficient and accurate repair of DNA lesions. Here we review changes to the chromatin structure that are intrinsic to the DNA damage response and the available mechanistic insight into how these chromatin changes facilitate distinct stages of the DNA damage repair pathways to maintain genomic stability." @default.
- W2087957210 created "2016-06-24" @default.
- W2087957210 creator A5024705451 @default.
- W2087957210 creator A5027937292 @default.
- W2087957210 creator A5042369850 @default.
- W2087957210 date "2012-01-17" @default.
- W2087957210 modified "2023-09-27" @default.
- W2087957210 title "Epigenetic regulation of genomic integrity" @default.
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