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• W2087960503 startingPage "255" @default.
• W2087960503 abstract "The treatment of invasive aspergillosis requires the use of drugs that characteristically have complex pharmacokinetic properties, the knowledge of which is essential to achieve maximum efficacy with minimal risk to the patient. The lipid-based amphotericin B formulations vary significantly in their pharmacokinetic behaviour, with very high plasma concentrations of the liposomal form, probably related to the presence of cholesterol in their structure. Azoles have a variable absorption profile, particularly in the case of itraconazole and posaconazole, with the latter very dependent on multiple factors. This may also lead to variations in voriconazole, which requires considering the possibility of monitoring plasma concentrations. The aim of this article is to review some of the most relevant aspects of the pharmacology of the antifungals used in the prophylaxis and treatment of the Aspergillus infection. For this reason, it includes the most relevant features of some of the azoles normally prescribed in this infection (itraconazole, posaconazole and voriconazole) and the amphotericin B formulations." @default.
• W2087960503 created "2016-06-24" @default.
• W2087960503 creator A5000000103 @default.
• W2087960503 creator A5009914543 @default.
• W2087960503 creator A5053107368 @default.
• W2087960503 date "2014-10-01" @default.
• W2087960503 modified "2023-10-01" @default.
• W2087960503 title "Farmacología de los antifúngicos en el tratamiento de la aspergilosis" @default.
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