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• W2087963983 abstract "We have investigated the effect of all-trans Retinoic acid, and of substances (Hemine and Hexamethylene bisacetamide) which interfere with in vitro differentiation of mesenchyme derived cell lineages on the expression of specific markers of hyperthrophy in in vitro differentiating chick embryo chondrocytes. (Castagnola P., et al., 1986). Continuous treatment of chondrogenic cells in conditions allowing differentiation in vitro with Retinoic acid resulted in persistence of type I collagen synthesis and in lack of type X collagen and Ch 21 protein expression. Hemin treated cells secreted a reduced amount of type X collagen. HMBA treatment inhibited type X collagen expression and caused reduction of the ratio between type II collagen and Ch 21 synthesized. The data indicate an independent regulation of these markers during chondrocyte differentiation." @default.
• W2087963983 created "2016-06-24" @default.
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• W2087963983 date "1992-01-01" @default.
• W2087963983 modified "2023-09-27" @default.
• W2087963983 title "Retinoic acid, hemin and hexamethylen bisacetamide interference with “in vitro” differentiation of chick embryo chondrocytes" @default.
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• W2087963983 doi "https://doi.org/10.1016/s0309-1651(06)80158-x" @default.
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