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- W2087967110 abstract "PROBLEM: Limited information is available on potential differences in sensitivity to urogenital infections between pregnant and nonpregnant hosts. METHOD OF STUDY: In this study, we evaluated Escherichia coli infectious complications in pregnant and nonpregnant rats and the effect of nitric oxide (NO) inhibitor, NG-nitro-l-arginine methyl ester (l-NAME), on the outcome of an experimental uterine infection. RESULTS: Of the infected pregnant animals, 31% were found dead in 24–48 hr. The death rate was increased 2-fold (66%) with l-NAME treatment. No deaths occurred in nonpregnant animals with or without l-NAME treatment. The rate of uterine infection in pregnant animals was about 10-fold higher than in nonpregnant animals. CONCLUSION: We propose that infectious complications of pregnancy may be related to gestation-dependent sensitivity to the pathogenic microorganism and the host NO status." @default.
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- W2087967110 date "1997-10-01" @default.
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- W2087967110 title "Lethal Outcome of Uterine Infection in Pregnant but Not in Nonpregnant Rats and Increased Death Rate With Inhibition of Nitric Oxide" @default.
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- W2087967110 doi "https://doi.org/10.1111/j.1600-0897.1997.tb00521.x" @default.
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