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- W2087981133 abstract "Cell suspensions, obtained from bone marrow, spleen, thymus, lung, liver, and from peritoneal washings, were incubated in vitro with low concentrations of endo-toxin and the supernatant media assayed for colony-stimulating activity (CSA). Peritoneal cells were markedly responsive. The kinetics of CSA production in vitro by peritoneal cells were not remarkably different from that seen in vivo following intravenous administration of endotoxin. The activities of CSA prepared from peritoneal cells and serum were compared following serial dilution; both gave a similar linear relationship when plotted as a function of log-concentration. The bulk of the CSA was produced by adherent peritoneal cells. Separation of peritoneal cells by velocity sedimentation showed that the CSA-producing cell had a sedimentation velocity of 7 mm/hr. Cells with this sedimentation velocity were found to be large mononuclear cells which demonstrated adherence and phagocytosis." @default.
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- W2087981133 date "1974-01-01" @default.
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- W2087981133 title "IN VITRO PRODUCTION OF COLONY-STIMULATING ACTIVITY. I. EXPOSURE OF MOUSE PERITONEAL CELLS TO ENDOTOXIN" @default.
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- W2087981133 doi "https://doi.org/10.1111/j.1365-2184.1974.tb00395.x" @default.
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