FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087982528> ?p ?o ?g. }

• W2087982528 endingPage "273" @default.
• W2087982528 startingPage "265" @default.
• W2087982528 abstract "In order to delineate mechanisms of noise-induced hearing loss, we assessed noise trauma and its pharmacological modulation in the guinea pig. Auditory threshold shifts (measured by auditory brainstem responses), hair cell loss and lipid peroxidation (8-isoprostane formation) were determined in the absence or presence of agents known to influence the formation or action of reactive oxygen species (ROS): the non-specific N-methyl-D-aspartate (NMDA) receptor antagonist (+)-MK-801, its inactive isomer (-)-MK-801, the selective NR1/2B NMDA receptor antagonist PD 174494, the nitric oxide synthase (NOS) inhibitor L-N(omega)-Nitroarginine methyl ester (L-NAME) and the anti-oxidant N-acetylcysteine (NAC). (+)-MK-801 and NAC attenuated threshold shifts and hair cell loss effectively while PD 174494 did so partially. L-NAME attenuated threshold shifts at 2 kHz but increased them at 20 kHz, and (-)-MK-801 was ineffective. Noise-induced elevation in 8-isoprostane in the cochlea was significantly attenuated by (+)-MK-801 and PD 174494 in the organ of Corti and modiolar core, by L-NAME in the lateral wall and modiolar core, and by NAC in all three regions. (-)-MK-801 did not influence noise-induced 8-isoprostane formation. There was a significant correlation between threshold shifts at 4 kHz, hair cell loss and the level of 8-isoprostane formed in the organ of Corti, but not in the lateral wall tissues. This finding suggests a causal relationship between ROS formation and functional and morphological damage. NMDA receptors and, to some extent, NOS may be involved in noise-induced ROS formation. The data also indicate that lipid peroxidation in the lateral wall tissues does not influence permanent threshold shifts." @default.
• W2087982528 created "2016-06-24" @default.
• W2087982528 creator A5006994500 @default.
• W2087982528 creator A5026655274 @default.
• W2087982528 creator A5051149885 @default.
• W2087982528 date "2003-03-01" @default.
• W2087982528 modified "2023-10-10" @default.
• W2087982528 title "Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea" @default.
• W2087982528 cites W1572697206 @default.
• W2087982528 cites W1606988289 @default.
• W2087982528 cites W1809136836 @default.
• W2087982528 cites W1966141870 @default.
• W2087982528 cites W1972153352 @default.
• W2087982528 cites W1982514916 @default.
• W2087982528 cites W1985499785 @default.
• W2087982528 cites W1989477058 @default.
• W2087982528 cites W1992667349 @default.
• W2087982528 cites W1999478664 @default.
• W2087982528 cites W2000540296 @default.
• W2087982528 cites W2004274364 @default.
• W2087982528 cites W2005515353 @default.
• W2087982528 cites W2010969292 @default.
• W2087982528 cites W2019043660 @default.
• W2087982528 cites W2019136614 @default.
• W2087982528 cites W2019814232 @default.
• W2087982528 cites W2034769077 @default.
• W2087982528 cites W2035258484 @default.
• W2087982528 cites W2041703880 @default.
• W2087982528 cites W2044813222 @default.
• W2087982528 cites W2058699456 @default.
• W2087982528 cites W2059379142 @default.
• W2087982528 cites W2061393008 @default.
• W2087982528 cites W2071233035 @default.
• W2087982528 cites W2074391555 @default.
• W2087982528 cites W2074791575 @default.
• W2087982528 cites W2075639702 @default.
• W2087982528 cites W2075910499 @default.
• W2087982528 cites W2078291178 @default.
• W2087982528 cites W2083623712 @default.
• W2087982528 cites W2099901207 @default.
• W2087982528 cites W2107442441 @default.
• W2087982528 cites W2112511374 @default.
• W2087982528 cites W2113803576 @default.
• W2087982528 cites W2131194264 @default.
• W2087982528 cites W2154265438 @default.
• W2087982528 cites W2163461292 @default.
• W2087982528 cites W2437174840 @default.
• W2087982528 cites W4239176618 @default.
• W2087982528 cites W4293247451 @default.
• W2087982528 doi "https://doi.org/10.1016/s0006-8993(02)04205-1" @default.
• W2087982528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12618349" @default.
• W2087982528 hasPublicationYear "2003" @default.
• W2087982528 type Work @default.
• W2087982528 sameAs 2087982528 @default.
• W2087982528 citedByCount "156" @default.
• W2087982528 countsByYear W20879825282012 @default.
• W2087982528 countsByYear W20879825282013 @default.
• W2087982528 countsByYear W20879825282014 @default.
• W2087982528 countsByYear W20879825282015 @default.
• W2087982528 countsByYear W20879825282016 @default.
• W2087982528 countsByYear W20879825282017 @default.
• W2087982528 countsByYear W20879825282018 @default.
• W2087982528 countsByYear W20879825282019 @default.
• W2087982528 countsByYear W20879825282020 @default.
• W2087982528 countsByYear W20879825282021 @default.
• W2087982528 countsByYear W20879825282022 @default.
• W2087982528 countsByYear W20879825282023 @default.
• W2087982528 crossrefType "journal-article" @default.
• W2087982528 hasAuthorship W2087982528A5006994500 @default.
• W2087982528 hasAuthorship W2087982528A5026655274 @default.
• W2087982528 hasAuthorship W2087982528A5051149885 @default.
• W2087982528 hasConcept C102793881 @default.
• W2087982528 hasConcept C126322002 @default.
• W2087982528 hasConcept C134018914 @default.
• W2087982528 hasConcept C169760540 @default.
• W2087982528 hasConcept C170493617 @default.
• W2087982528 hasConcept C185592680 @default.
• W2087982528 hasConcept C2776151105 @default.
• W2087982528 hasConcept C2776885963 @default.
• W2087982528 hasConcept C2777622882 @default.
• W2087982528 hasConcept C2778010969 @default.
• W2087982528 hasConcept C2778122271 @default.
• W2087982528 hasConcept C2778585322 @default.
• W2087982528 hasConcept C2779356876 @default.
• W2087982528 hasConcept C2780130748 @default.
• W2087982528 hasConcept C2780493683 @default.
• W2087982528 hasConcept C2780659331 @default.
• W2087982528 hasConcept C2780829032 @default.
• W2087982528 hasConcept C3018332767 @default.
• W2087982528 hasConcept C519581460 @default.
• W2087982528 hasConcept C548259974 @default.
• W2087982528 hasConcept C55493867 @default.
• W2087982528 hasConcept C67018056 @default.
• W2087982528 hasConcept C71924100 @default.
• W2087982528 hasConcept C86803240 @default.
• W2087982528 hasConceptScore W2087982528C102793881 @default.
• W2087982528 hasConceptScore W2087982528C126322002 @default.
• W2087982528 hasConceptScore W2087982528C134018914 @default.

• next