Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087995718> ?p ?o ?g. }
- W2087995718 endingPage "59" @default.
- W2087995718 startingPage "54" @default.
- W2087995718 abstract "Purpose of review The purpose of this review is to understand the role of the host immune system in clearing the human papillomavirus (HPV) infection, strategies adopted by HPV to subvert the host immune responses and analyze the challenges to the future immunotherapeutic treatment modalities. Recent findings Cervical epithelium provides a protective niche to the virus to subvert the immune responses. The absence of an inflammatory milieu in the cervix makes the resident dendritic and langerhan cells tolerogenic to HPV antigens. CD4+ cells predominated in regressing cervical intraepithelial neoplasia lesions, whereas CD8+ cells were dominant in invasive carcinoma. A reduced expression of T cell signaling molecule T-cell receptor zeta chain was observed in CD8+ lymphocytes. Decreased numbers of NKG2D expressing natural killer and T cells were present in patients with cervical cancer and cervical intraepithelial neoplasia. Increased frequencies of CD4+ CD25+ FoxP3+ T regulatory cells were observed in patients with cervical cancer. The Nrp-1+Treg showed greater suppressive activity. A network of Treg and indoleamine 2, 3-dioxygenase expressed in tumor cells facilitates immune escape of tumor cells. Summary The HPV uses different strategies to evade immune recognition. Understanding the immune evasion mechanisms used by HPV will help in designing newer therapeutic strategies for cervical cancer." @default.
- W2087995718 created "2016-06-24" @default.
- W2087995718 creator A5023111049 @default.
- W2087995718 creator A5042396485 @default.
- W2087995718 date "2009-02-01" @default.
- W2087995718 modified "2023-09-24" @default.
- W2087995718 title "Host immune responses to cervical cancer" @default.
- W2087995718 cites W1901303328 @default.
- W2087995718 cites W1964888441 @default.
- W2087995718 cites W1966452991 @default.
- W2087995718 cites W1978416120 @default.
- W2087995718 cites W1984980936 @default.
- W2087995718 cites W1986847770 @default.
- W2087995718 cites W1991713356 @default.
- W2087995718 cites W1997937844 @default.
- W2087995718 cites W1999764998 @default.
- W2087995718 cites W2001005710 @default.
- W2087995718 cites W2001976179 @default.
- W2087995718 cites W2008242826 @default.
- W2087995718 cites W2014176736 @default.
- W2087995718 cites W2015416044 @default.
- W2087995718 cites W2019275002 @default.
- W2087995718 cites W2021427213 @default.
- W2087995718 cites W2026322085 @default.
- W2087995718 cites W2034625094 @default.
- W2087995718 cites W2035809809 @default.
- W2087995718 cites W2036069120 @default.
- W2087995718 cites W2037787205 @default.
- W2087995718 cites W2041647202 @default.
- W2087995718 cites W2042349690 @default.
- W2087995718 cites W2054140880 @default.
- W2087995718 cites W2055093813 @default.
- W2087995718 cites W2058527604 @default.
- W2087995718 cites W2063557216 @default.
- W2087995718 cites W2066867563 @default.
- W2087995718 cites W2078990740 @default.
- W2087995718 cites W2082927988 @default.
- W2087995718 cites W2086141003 @default.
- W2087995718 cites W2086408819 @default.
- W2087995718 cites W2087333240 @default.
- W2087995718 cites W2089265092 @default.
- W2087995718 cites W2098491904 @default.
- W2087995718 cites W2098765233 @default.
- W2087995718 cites W2100352133 @default.
- W2087995718 cites W2101215934 @default.
- W2087995718 cites W2104486165 @default.
- W2087995718 cites W2109250135 @default.
- W2087995718 cites W2110404633 @default.
- W2087995718 cites W2111220263 @default.
- W2087995718 cites W2112859230 @default.
- W2087995718 cites W2127242165 @default.
- W2087995718 cites W2129057663 @default.
- W2087995718 cites W2137560059 @default.
- W2087995718 cites W2159831861 @default.
- W2087995718 cites W2166010149 @default.
- W2087995718 cites W2170785298 @default.
- W2087995718 doi "https://doi.org/10.1097/gco.0b013e32831a9890" @default.
- W2087995718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19125004" @default.
- W2087995718 hasPublicationYear "2009" @default.
- W2087995718 type Work @default.
- W2087995718 sameAs 2087995718 @default.
- W2087995718 citedByCount "74" @default.
- W2087995718 countsByYear W20879957182012 @default.
- W2087995718 countsByYear W20879957182013 @default.
- W2087995718 countsByYear W20879957182014 @default.
- W2087995718 countsByYear W20879957182015 @default.
- W2087995718 countsByYear W20879957182016 @default.
- W2087995718 countsByYear W20879957182017 @default.
- W2087995718 countsByYear W20879957182018 @default.
- W2087995718 countsByYear W20879957182019 @default.
- W2087995718 countsByYear W20879957182020 @default.
- W2087995718 countsByYear W20879957182021 @default.
- W2087995718 countsByYear W20879957182022 @default.
- W2087995718 countsByYear W20879957182023 @default.
- W2087995718 crossrefType "journal-article" @default.
- W2087995718 hasAuthorship W2087995718A5023111049 @default.
- W2087995718 hasAuthorship W2087995718A5042396485 @default.
- W2087995718 hasConcept C121608353 @default.
- W2087995718 hasConcept C126322002 @default.
- W2087995718 hasConcept C167672396 @default.
- W2087995718 hasConcept C203014093 @default.
- W2087995718 hasConcept C2777343196 @default.
- W2087995718 hasConcept C2778220009 @default.
- W2087995718 hasConcept C2779727006 @default.
- W2087995718 hasConcept C502942594 @default.
- W2087995718 hasConcept C71924100 @default.
- W2087995718 hasConcept C8891405 @default.
- W2087995718 hasConceptScore W2087995718C121608353 @default.
- W2087995718 hasConceptScore W2087995718C126322002 @default.
- W2087995718 hasConceptScore W2087995718C167672396 @default.
- W2087995718 hasConceptScore W2087995718C203014093 @default.
- W2087995718 hasConceptScore W2087995718C2777343196 @default.
- W2087995718 hasConceptScore W2087995718C2778220009 @default.
- W2087995718 hasConceptScore W2087995718C2779727006 @default.
- W2087995718 hasConceptScore W2087995718C502942594 @default.
- W2087995718 hasConceptScore W2087995718C71924100 @default.
- W2087995718 hasConceptScore W2087995718C8891405 @default.
- W2087995718 hasIssue "1" @default.