FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2088003671> ?p ?o ?g. }

• W2088003671 endingPage "279" @default.
• W2088003671 startingPage "265" @default.
• W2088003671 abstract "Spinal cord injury (SCI) remains a common and devastating problem of modern society. Through an understanding of underlying pathophysiologic mechanisms involved in the evolution of SCI, treatments aimed at ameliorating neural damage may be developed. The possible pharmacologic treatments for acute spinal cord injury are herein reviewed. Myriad treatment modalities, including corticosteroids, 21-aminosteroids, opioid receptor antagonists, gangliosides, thyrotropin-releasing hormone (TRH) and TRH analogs, antioxidants and free radical scavengers, calcium channel blockers, magnesium replacement therapy, sodium channel blockers, N-methyl-D-aspartate receptor antagonists, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid–kainate receptor antagonists, modulators of arachadonic acid metabolism, neurotrophic growth factors, serotonin antagonists, antibodies against inhibitors of axonal regeneration, potassium channel blockers (4-aminopyridine), paclitaxel, clenbuterol, progesterone, gabexate mesylate, activated protein C, caspase inhibitors, tacrolimus, antibodies against adhesion molecules, and other immunomodulatory therapy have been studied to date. Although most of these agents have shown promise, only one agent, methylprednisolone, has been shown to provide benefit in large clinical trials. Given these data, many individuals consider methylprednisolone to be the standard of care for the treatment of acute SCI. However, this has not been established definitively, and questions pertaining to methodology have emerged regarding the National Acute Spinal Cord Injury Study trials that provided these conclusions. Additionally, the clinical significance (in contrast to statistical significance) of recovery after methylprednisolone treatment is unclear and must be considered in light of the potential adverse effects of such treatment. This first decade of the new millennium, now touted as the Decade of the Spine, will hopefully witness the emergence of universal and efficacious pharmacologic therapy and ultimately a cure for SCI." @default.
• W2088003671 created "2016-06-24" @default.
• W2088003671 creator A5014415723 @default.
• W2088003671 creator A5015458601 @default.
• W2088003671 creator A5016270829 @default.
• W2088003671 creator A5029198298 @default.
• W2088003671 creator A5059146591 @default.
• W2088003671 creator A5077859542 @default.
• W2088003671 creator A5080334509 @default.
• W2088003671 date "2001-09-01" @default.
• W2088003671 modified "2023-10-16" @default.
• W2088003671 title "Acute Spinal Cord Injury, Part II: Contemporary Pharmacotherapy" @default.
• W2088003671 cites W1510677902 @default.
• W2088003671 cites W1515821225 @default.
• W2088003671 cites W1530777667 @default.
• W2088003671 cites W1552175551 @default.
• W2088003671 cites W1841924923 @default.
• W2088003671 cites W1907724378 @default.
• W2088003671 cites W1928750263 @default.
• W2088003671 cites W1947829569 @default.
• W2088003671 cites W1964669724 @default.
• W2088003671 cites W1968928244 @default.
• W2088003671 cites W1970929135 @default.
• W2088003671 cites W1971304382 @default.
• W2088003671 cites W1971523172 @default.
• W2088003671 cites W1971801662 @default.
• W2088003671 cites W1974188769 @default.
• W2088003671 cites W1974824689 @default.
• W2088003671 cites W1979623498 @default.
• W2088003671 cites W1979929855 @default.
• W2088003671 cites W1980177820 @default.
• W2088003671 cites W1982933615 @default.
• W2088003671 cites W1985185792 @default.
• W2088003671 cites W1986343337 @default.
• W2088003671 cites W1989908121 @default.
• W2088003671 cites W1991534074 @default.
• W2088003671 cites W1992861384 @default.
• W2088003671 cites W1993802713 @default.
• W2088003671 cites W1994976436 @default.
• W2088003671 cites W1996449070 @default.
• W2088003671 cites W1997394926 @default.
• W2088003671 cites W1998919607 @default.
• W2088003671 cites W1999244829 @default.
• W2088003671 cites W1999997856 @default.
• W2088003671 cites W2000057840 @default.
• W2088003671 cites W2000655734 @default.
• W2088003671 cites W2001644009 @default.
• W2088003671 cites W2002422337 @default.
• W2088003671 cites W2004625416 @default.
• W2088003671 cites W2009191172 @default.
• W2088003671 cites W2010905770 @default.
• W2088003671 cites W2011411078 @default.
• W2088003671 cites W2013035816 @default.
• W2088003671 cites W2014203854 @default.
• W2088003671 cites W2014676055 @default.
• W2088003671 cites W2014707120 @default.
• W2088003671 cites W2018715825 @default.
• W2088003671 cites W2022304320 @default.
• W2088003671 cites W2022328640 @default.
• W2088003671 cites W2024623367 @default.
• W2088003671 cites W2025778924 @default.
• W2088003671 cites W2025925630 @default.
• W2088003671 cites W2026098217 @default.
• W2088003671 cites W2026285175 @default.
• W2088003671 cites W2026608661 @default.
• W2088003671 cites W2028849594 @default.
• W2088003671 cites W2028994197 @default.
• W2088003671 cites W2029768920 @default.
• W2088003671 cites W2030676523 @default.
• W2088003671 cites W2031433365 @default.
• W2088003671 cites W2032079164 @default.
• W2088003671 cites W2032304318 @default.
• W2088003671 cites W2033091937 @default.
• W2088003671 cites W2033828028 @default.
• W2088003671 cites W2034167677 @default.
• W2088003671 cites W2034275018 @default.
• W2088003671 cites W2034692936 @default.
• W2088003671 cites W2035254789 @default.
• W2088003671 cites W2039188961 @default.
• W2088003671 cites W2039721791 @default.
• W2088003671 cites W2040751295 @default.
• W2088003671 cites W2041230353 @default.
• W2088003671 cites W2041815931 @default.
• W2088003671 cites W2045414227 @default.
• W2088003671 cites W2045752665 @default.
• W2088003671 cites W2047317904 @default.
• W2088003671 cites W2047369546 @default.
• W2088003671 cites W2049698192 @default.
• W2088003671 cites W2050415048 @default.
• W2088003671 cites W2051395367 @default.
• W2088003671 cites W2053985129 @default.
• W2088003671 cites W2054404263 @default.
• W2088003671 cites W2056031482 @default.
• W2088003671 cites W2057040880 @default.
• W2088003671 cites W2060594848 @default.
• W2088003671 cites W2061382584 @default.
• W2088003671 cites W2064615085 @default.
• W2088003671 cites W2064619205 @default.

• next