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- W2088005364 startingPage "391" @default.
- W2088005364 abstract "Abstract Blood haemostasis is accomplished by a complex network of coagulatory and fibrinolytic processes. These processes have to be delicately balanced, as clinically manifested by bleeding disorders, such as haemophilia A and B. These disorders are caused by defects in coagulation factor VIII and factor IX, respectively. Following a dual strategy, we emphasise on the one hand principles conserved in most coagulation enzymes, thus mirroring much of the underlying complexity in haemostasis; on the other hand, we identify enzymatic properties of the factor IXa-factor VIIIa system (Xase) that distinguish this proteolytic machine from other components of the coagulation system. While the exact mechanisms of its activity modulation remain baffling until today, superactive factor IX mutants significantly improve our current understanding and serve as a specific and testable model of Xase action." @default.
- W2088005364 created "2016-06-24" @default.
- W2088005364 creator A5023287358 @default.
- W2088005364 creator A5086925455 @default.
- W2088005364 date "2009-04-10" @default.
- W2088005364 modified "2023-10-18" @default.
- W2088005364 title "Activation mechanisms of coagulation factor IX" @default.
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- W2088005364 doi "https://doi.org/10.1515/bc.2009.057" @default.
- W2088005364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19361276" @default.
- W2088005364 hasPublicationYear "2009" @default.
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