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- W2088016816 abstract "Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities of metazoan gene regulation. We studied by ChIP-chip the genome-wide binding sites of 6 insulator-associated proteins-dCTCF, CP190, BEAF-32, Su(Hw), Mod(mdg4), and GAF-to obtain the first comprehensive map of insulator elements in Drosophila embryos. We identify over 14,000 putative insulators, including all classically defined insulators. We find two major classes of insulators defined by dCTCF/CP190/BEAF-32 and Su(Hw), respectively. Distributional analyses of insulators revealed that particular sub-classes of insulator elements are excluded between cis-regulatory elements and their target promoters; divide differentially expressed, alternative, and divergent promoters; act as chromatin boundaries; are associated with chromosomal breakpoints among species; and are embedded within active chromatin domains. Together, these results provide a map demarcating the boundaries of gene regulatory units and a framework for understanding insulator function during the development and evolution of Drosophila." @default.
- W2088016816 created "2016-06-24" @default.
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- W2088016816 date "2010-01-15" @default.
- W2088016816 modified "2023-10-18" @default.
- W2088016816 title "A Comprehensive Map of Insulator Elements for the Drosophila Genome" @default.
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- W2088016816 cites W1971470482 @default.
- W2088016816 cites W1973342161 @default.
- W2088016816 cites W1973534367 @default.
- W2088016816 cites W1973726475 @default.
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- W2088016816 cites W1986809672 @default.
- W2088016816 cites W1989373989 @default.
- W2088016816 cites W1996270170 @default.
- W2088016816 cites W2004060771 @default.
- W2088016816 cites W2008543992 @default.
- W2088016816 cites W2017840637 @default.
- W2088016816 cites W2019937806 @default.
- W2088016816 cites W2027781138 @default.
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- W2088016816 cites W2066170392 @default.
- W2088016816 cites W2067563155 @default.
- W2088016816 cites W2070126970 @default.
- W2088016816 cites W2070168243 @default.
- W2088016816 cites W2085932408 @default.
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- W2088016816 cites W2094157761 @default.
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- W2088016816 cites W2097803426 @default.
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- W2088016816 cites W2101291169 @default.
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- W2088016816 cites W2122439070 @default.
- W2088016816 cites W2124435146 @default.
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- W2088016816 cites W2128385074 @default.
- W2088016816 cites W2136583745 @default.
- W2088016816 cites W2138315073 @default.
- W2088016816 cites W2139412202 @default.
- W2088016816 cites W2140369335 @default.
- W2088016816 cites W2141222206 @default.
- W2088016816 cites W2142232604 @default.
- W2088016816 cites W2143255831 @default.
- W2088016816 cites W2145380525 @default.
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- W2088016816 doi "https://doi.org/10.1371/journal.pgen.1000814" @default.
- W2088016816 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2797089" @default.
- W2088016816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20084099" @default.
- W2088016816 hasPublicationYear "2010" @default.
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